1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
    5-HT Receptor
  3. (S)-Amisulpride

(S)-Amisulpride (Synonyms: Esamisulpride; SEP-4199)

Cat. No.: HY-126068
Handling Instructions

(S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a KI of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects.

For research use only. We do not sell to patients.

(S)-Amisulpride Chemical Structure

(S)-Amisulpride Chemical Structure

CAS No. : 71675-92-8

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Description

(S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a KI of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects[1][2].

IC50 & Target[1][2]

D2 Receptor

 

D3 Receptor

 

5-HT7 Receptor

900 nM (Ki)

In Vitro

(S)-Amisulpride (Esamisulpride) displays high affinity binding at both D2 and D3 receptors and is approximately twice as potent as racamisulpride and 20–50 times more potent than (R)-amisulpride at these receptors[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The (S)-amisulpride (10mg/kg, s.c.) stimulus is rapidly acquired and was shown to be dose-related, time dependent (effective between 30 and 120min) and stereoselective male C57BL/6 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

369.48

Formula

C₁₇H₂₇N₃O₄S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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(S)-Amisulpride
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