HDAC-IN-102
HDAC-IN-102 (Compound 21) is a histone deacetylase (HDAC) inhibitor with an IC50 of 58 μM. HDAC-IN-102 inhibits total HDAC activity and exhibits partial subtype selectivity, with the R-isomer targeting HDAC2 and the S-isomer targeting HDAC8. HDAC-IN-102 exerts antioxidant effects by scavenging DPPH free radicals. HDAC-IN-102 can be used in cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 626200-64-4
- Formula: C18H28O4
- Molecular Weight:308.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
100 μM
Compound: D5
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by WST1 assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by WST1 assay
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[PMID: 28065501] |
HDAC-IN-102 (1-100 μM; 5-15 min) inhibits total HDAC activity in HeLa nuclear extracts, with an IC50 of 58 μM[1].
HDAC-IN-102 (30 min) acts as a DPPH free radical scavenger with an IC50 value of 48 μM, and exhibits antioxidant activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 626200-64-4
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Molecular Weight 308.41
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Formula C18H28O4
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SMILES
O=C(CC(CCCCC)OC)CCC1=CC=C(C(OC)=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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