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(S)-AMG-628

(S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374). (S)-AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448)- and acid-induced Ca2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA-(HY-153808) induced inflammatory pain models.

For research use only. We do not sell to patients.

  • CAS No.: 862269-92-9
  • Formula: C25H25FN6O2S
  • Molecular Weight:492.57
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • (S)-AMG-628 Chemical Structure
    (S)-AMG-628 Chemical Structure
CAS No.: 862269-92-9
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All TRP Channel Isoforms

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  • (S)-AMG-628 Chemical Structure
    (S)-AMG-628 Chemical Structure
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  • (S)-AMG-628