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Referencia número: HY-123374

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(Rac)-AMG 628

(Rac)-AMG 628 is the racemate of AMG 628, a potent TRPV1 antagonist with an IC₅₀ of 3.7nM. AMG 628 can be used in chronic pain research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 862269-73-6
Fòrmula: C₂₅H₂₅FN₆O₂S
Peso molecular:492.57

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

(Rac)-AMG 628 Chemical Structure

No. CAS: 862269-73-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

(Rac)-AMG 628 is the racemate of AMG 628, a potent TRPV1 antagonist with an IC₅₀ of 3.7nM. AMG 628 can be used in chronic pain research^[1].

Ver todos los productos específicos de isoformas TRP Channel :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	3.1 nM Compound: 17a	Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx	[PMID: 17585751]
CHO	IC₅₀	4.9 nM Compound: 17a	Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx	[PMID: 17585751]

Chemical Information

No. CAS 862269-73-6
Peso molecular 492.57
Fòrmula C₂₅H₂₅FN₆O₂S
SMILES

CC(NC1=NC2=C(OC3=NC=NC(N4CCN(C(C5=CC=C(F)C=C5)C)CC4)=C3)C=CC=C2S1)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Thiel OR, et al. Practical synthesis of a vanilloid receptor-1 antagonist. J Org Chem. 2008 May 2;73(9):3508-15. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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