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Cat. No.: HY-123374

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(Rac)-AMG 628

(Rac)-AMG 628 is the racemate of AMG 628, a potent TRPV1 antagonist with an IC₅₀ of 3.7nM. AMG 628 can be used in chronic pain research.

For research use only. We do not sell to patients.

CAS No.: 862269-73-6
Formula: C₂₅H₂₅FN₆O₂S
Molecular Weight:492.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

(Rac)-AMG 628 Chemical Structure

CAS No.: 862269-73-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

(Rac)-AMG 628 is the racemate of AMG 628, a potent TRPV1 antagonist with an IC₅₀ of 3.7nM. AMG 628 can be used in chronic pain research^[1].

All TRP Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	3.1 nM Compound: 17a	Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx	[PMID: 17585751]
CHO	IC₅₀	4.9 nM Compound: 17a	Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx	[PMID: 17585751]

Chemical Information

CAS No. 862269-73-6
Molecular Weight 492.57
Formula C₂₅H₂₅FN₆O₂S
SMILES

CC(NC1=NC2=C(OC3=NC=NC(N4CCN(C(C5=CC=C(F)C=C5)C)CC4)=C3)C=CC=C2S1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thiel OR, et al. Practical synthesis of a vanilloid receptor-1 antagonist. J Org Chem. 2008 May 2;73(9):3508-15. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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