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Cat. No.: HY-W931056

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AMG-628

AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin (HY-10448) or acid (pH 5)-induced Ca²⁺ influx into TRPV1- expressing CHO cell with IC₅₀ of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448)-induced rat model, and exhibits a half-life of 2.4 h in rats.

For research use only. We do not sell to patients.

CAS No.: 862269-93-0
Formula: C₂₅H₂₅FN₆O₂S
Molecular Weight:492.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

AMG-628 Chemical Structure

CAS No.: 862269-93-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All TRP Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	2 nM Compound: 16p, AMG-628	Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx Inhibition of rat TRPV1 expressed in CHO cells assessed as acid-induced Ca2+ influx	[PMID: 17585751]
CHO	IC₅₀	3.7 nM Compound: 16p, AMG-628	Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx Inhibition of rat TRPV1 expressed in CHO cells assessed as capsaicin-induced Ca2+ influx	[PMID: 17585751]

Chemical Information

CAS No. 862269-93-0
Molecular Weight 492.57
Formula C₂₅H₂₅FN₆O₂S
SMILES

CC(NC1=NC2=C(OC3=NC=NC(N4CCN([C@@H](C5=CC=C(F)C=C5)C)CC4)=C3)C=CC=C2S1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang HL, et al., Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J Med Chem. 2007 Jul 26;50(15):3528-39. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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