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Results for "

5 lo Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (1) Biochemical Assay Reagents (1) COX (4) DNA/RNA Synthesis (2) Endogenous Metabolite (1) Ferroptosis (3) Glucosidase (1) Leukotriene Receptor (2) Lipoxygenase (22) Microtubule/Tubulin (1) PGE synthase (1) Phospholipase (2) TGF-beta/Smad (1) TRP Channel (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (15) Metabolic Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Targets Recommended: FLAP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00156

Lonapalene

RS4317
Lipoxygenase Inflammation/Immunology

Lonapalene (RS4317) is a topically effective 5-lipoxygenase (5-LO) inhibitor.

Lonapalene RS4317	Lipoxygenase	Inflammation/Immunology
Lonapalene (RS4317) is a topically effective 5-lipoxygenase (5-LO) inhibitor.

HY-N0172

Caffeic acid 3 Publications Verification	TRP Channel Lipoxygenase Endogenous Metabolite	Inflammation/Immunology Cancer
Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).

HY-U00260

CMI977

LDP977
Lipoxygenase Inflammation/Immunology

CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.

CMI977 LDP977	Lipoxygenase	Inflammation/Immunology
CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.

HY-U00347

COX/5-LO-IN-1 Atreleuton analog	COX Lipoxygenase	Inflammation/Immunology
COX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase and 5-lipoxygenase (5-LO), used for the research of inflammatory and allergic disease states.

HY-120502

5-LOX-IN-6	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC₅₀ values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research .

HY-12886

Docebenone

AA 861
Lipoxygenase Ferroptosis Inflammation/Immunology

Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

Docebenone AA 861	Lipoxygenase Ferroptosis	Inflammation/Immunology
Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

HY-106200

CJ-13,610	Lipoxygenase	Inflammation/Immunology
CJ-13,610, a nonredox-type *5-LO* inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC₅₀ of about 70 nM . PMNL: polymorphonuclear leukocytes; AA: arachidonic acid

HY-103157

PD146176 3 Publications Verification NSC168807	Autophagy Ferroptosis	Cardiovascular Disease
PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (K_i=197 nM, IC₅₀=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice .

HY-U00438

LP117

Lipoxygenase Inflammation/Immunology

LP117 is a novel and potent inhibitor of 5-Lipoxygenase (5-LO) product synthesis with an IC₅₀ of 1.1 μM.

LP117	Lipoxygenase	Inflammation/Immunology
LP117 is a novel and potent inhibitor of 5-Lipoxygenase (5-LO) product synthesis with an IC₅₀ of 1.1 μM.

HY-N2513

β-Boswellic acid	Lipoxygenase DNA/RNA Synthesis	Cancer
β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .

HY-13219

Tepoxalin	COX Lipoxygenase	Inflammation/Immunology
Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase (5-LO) with potent anti-inflammatory activity and a favorable gastrointestinal profile .

HY-N7162

3-O-Acetyl-11-hydroxy-beta-boswellic acid

Lipoxygenase Others

3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase (5-LO) inhibitor .

3-O-Acetyl-11-hydroxy-beta-boswellic acid	Lipoxygenase	Others
3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase *(5-LO)* inhibitor .

HY-13419

U-73122 Maximum Cited Publications 65 Publications Verification	Phospholipase Lipoxygenase Ferroptosis	Inflammation/Immunology
U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC₅₀of 1-2.1 µM for PLC.

HY-126898

5-LO/mPGES1-IN-1	Lipoxygenase PGE synthase	Inflammation/Immunology
5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC₅₀ values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity .

HY-N2513R

β-Boswellic acid (Standard)	Lipoxygenase DNA/RNA Synthesis	Cancer
β-Boswellic acid (Standard) is the analytical standard of β-Boswellic acid. This product is intended for research and analytical applications. β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .

HY-120495

EP6	Lipoxygenase	Cancer
EP6 is a potent 5-Lipoxygenase (5-LO) inhibitor. EP6 inhibits the cell viability of tumor cells without mutagenic activity. EP6 can be used in research of cancer .

HY-120539

Enofelast BI-L-239	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
Enofelast (BI-L-239), a 5-lipoxygenase (5-LO) inhibitor, exhibits an IC₅₀ of 2.48 μM for inhibition of calcium ionophore-induced LTB₄ generation .

HY-101945

A-69412	Lipoxygenase	Inflammation/Immunology
A-69412 is a reversible, specific inhibitor of the 5-lipoxygenase (5-LO). A-69412 has the potential to treat asthma and ulcerative colitis, and possibly other inflammatory and allergic conditions.

HY-10437

Setileuton MK-0633	Lipoxygenase	Inflammation/Immunology
Setileuton (MK-0633) is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC₅₀ of 3.9 and 52 nM, respectively .

HY-131384

8,11,14-Eicosatriynoic acid 8,11,14-Icosatriynoic acid	Biochemical Assay Reagents	Others
8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-19212

S-2474	COX Lipoxygenase	Inflammation/Immunology
S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC₅₀s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent.

HY-119671

BW 755C	COX Lipoxygenase	Endocrinology
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC₅₀ of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC₅₀s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively .

HY-108630

U-73343 3 Publications Verification	Phospholipase	Others
U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC₅₀ of 1-2.1 µM for PLC .

HY-W009757

Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate	Others	Others
Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate is an active compound, and can be used in the synthesis of 2-phenylthiomethyl-indole derivatives, 2-phenylthiomethyl-indole derivative is a 5-lipoxygenase (5-LO) inhibitor .

HY-117853

Atreleuton ABT-761; VIA-2291	Lipoxygenase	Cardiovascular Disease
Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation . Atreleuton is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N10426

(+)-Cembrene A	Glucosidase	Metabolic Disease
(+)-Cembrene A (Compound 5) is a α-glucosidase inhibitor with an IC₅₀ of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells .

HY-138688

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate CDC	Lipoxygenase	Metabolic Disease
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent 12/15-Lipoxygenases (LO) inhibitor. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate has the potential for the research of type 1 diabetes mellitus .

HY-N6896

Isoviolanthin	TGF-beta/Smad	Cancer
Isoviolanthin, a flavonoid glycoside, could markedly inhibit TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the TGF-β/Smad and PI3K/Akt/mTOR pathways in HCC cells. Isoviolanthin exhibits no cytotoxic effects on normal liver LO2 cells .

HY-146715

IDO/Tubulin-IN-2	Microtubule/Tubulin Apoptosis	Cancer
IDO/Tubulin-IN-2 (HT2) is a potent TDO and tubulin inhibitor. IDO/Tubulin-IN-2 also shows potent activity against U87, HepG2, A549, HCT-116, and LO2 cancer cell lines, with IC₅₀ values of 0.43, 0.036, 0.041, 0.095 and 1.04 μM, respectively. IDO/Tubulin-IN-2 remarkably promotes the antitumor activity .

8,11,14-Eicosatriynoic acid 8,11,14-Icosatriynoic acid	Biochemical Assay Reagents
8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Caffeic acid 3 Publications Verification	Structural Classification Classification of Application Fields Anti-aging Food Preservation Research Source classification Plants Endogenous metabolite Agricultural Research Human Gut Microbiota Metabolites other families Microorganisms Simple Phenylpropanols Sunscreen Phenols Polyphenols Phenylpropanoids Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer	TRP Channel Lipoxygenase Endogenous Metabolite
Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).

β-Boswellic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .

3-O-Acetyl-11-hydroxy-beta-boswellic acid	Triterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields	Lipoxygenase
3-O-Acetyl-11-hydroxy-beta-boswellic acid is a potent 5-lipoxygenase *(5-LO)* inhibitor .

β-Boswellic acid (Standard)	Structural Classification other families Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid (Standard) is the analytical standard of β-Boswellic acid. This product is intended for research and analytical applications. β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .

(+)-Cembrene A	Structural Classification Animals Terpenoids Source classification	Glucosidase
(+)-Cembrene A (Compound 5) is a α-glucosidase inhibitor with an IC₅₀ of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells .

Isoviolanthin	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	TGF-beta/Smad
Isoviolanthin, a flavonoid glycoside, could markedly inhibit TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the TGF-β/Smad and PI3K/Akt/mTOR pathways in HCC cells. Isoviolanthin exhibits no cytotoxic effects on normal liver LO2 cells .

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5 lo Inhibitors

Inhibitors & Agonists

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