1. Metabolic Enzyme/Protease
    Apoptosis
  2. Lipoxygenase
    Ferroptosis
  3. Docebenone

Docebenone (Synonyms: AA 861)

Cat. No.: HY-12886 Purity: 99.10%
Handling Instructions

Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

For research use only. We do not sell to patients.

Docebenone Chemical Structure

Docebenone Chemical Structure

CAS No. : 80809-81-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.

IC50 & Target

5-LO

 

In Vitro

Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production[1]. Docebenone at 10-200 μM increases [Ca2+]i concentration dependently[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Docebenone might protect experimental acute necrotizing pancreatitis in rats[3]. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10-8-10-5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10-8-10-5 M[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

326.43

Formula

C₂₁H₂₆O₃

CAS No.

80809-81-0

SMILES

O=C1C(CCCCC#CCCCC#CCO)=C(C)C(C(C)=C1C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (765.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0634 mL 15.3172 mL 30.6344 mL
5 mM 0.6127 mL 3.0634 mL 6.1269 mL
10 mM 0.3063 mL 1.5317 mL 3.0634 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (19.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[3]

Rats[3]
Pancreatitis is induced in rats by retrograde injection of 0.4 mL/kg body wt of 6% taurocholic acid into the pancreatic duct. The animals are divided into three groups: control group; administered Docebenone in a single dose of 30 mg/kg; and administered Docebenone in a single dose of 60 mg/kg. The following parameters are examined: serum amylase, lipase, trypsin, blood sugar, and survival rate[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

DocebenoneAA 861AA861AA-861LipoxygenaseFerroptosisLOXInhibitorinhibitorinhibit

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Docebenone
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