80809-81-0
80809-81-0
Chemical Structure
Docebenone
Synonym(s): AA 861
- CAS No.: 80809-81-0
- Formula:C21H26O3
- Molecular Weight:326.43
IUPAC Name: 2-(12-hydroxydodeca-5,10-diyn-1-yl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione
InChIKey: WDEABJKSGGRCQA-UHFFFAOYSA-N
SMILES: O=C1C(CCCCC#CCCCC#CCO)=C(C)C(C(C)=C1C)=O
Biological Activity: Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Docebenone | 99.02% | Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. | ||||||||||||||||||||
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Docebenone (Standard) | ≥98% | Docebenone (Standard) is the analytical standard of Docebenone. This product is intended for research and analytical applications. Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. | ||||||||||||||||||||
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Prostaglandin B2 | 98.99% | Prostaglandin B2 is a prostaglandin. Prostaglandin B2 is the main substance in cord blood mesenchymal stem cells, to inhibit DC-T Cell proliferation. Prostaglandin B2 also induces cutaneous vasoconstriction of the canine hind paw. | ||||||||||||||||||||
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AA-1777 | AA-1777 is an active compound. | |||||||||||||||||||||
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AA863 | AA863 is a 5-lipoxygenase inhibitor with activity in inhibiting the proliferation of human glioma cells. AA863 exhibits significant and dose-dependent inhibitory effects in monolayer cultured glioma cells with an IC50 of 9.0 micromolar. | |||||||||||||||||||||
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Utreloxastat | 99.32% | Utreloxastat (PTC857) is an orally active and blood-brain barrier-permeable 15-lipooxygenase inhibitor. Utreloxastat is a weak inhibitor of CYP1A2 and 2B6 with an IC50 of >5.3 μM. Utreloxastat reduces oxidative stress and inhibits the consumption of reduced glutathione and ferroptosis. Utreloxastat can be used in the study of neurodegenerative diseases characterized by high levels of oxidative stress and mitochondrial pathology, such as amyotrophic lateral sclerosisc. | ||||||||||||||||||||
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EPI-743 | 98.06% | EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione. | ||||||||||||||||||||
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Embelin | 99.01% | Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells. | ||||||||||||||||||||
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Decylplastoquinone | Decylplastoquinone is lipid-soluble derivative of plastoquinone (HY-N11882). Plastoquinone (PQ-9), a potent electron carrier, is an essential component of photosynthesis. Plastoquinone is also a redox sensor that regulates state transitions and gene expression. | |||||||||||||||||||||
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D-α-Tocopherylquinone | 98.08% | D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is an oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant. D-α-Tocopherylquinone reduces cellular oxidative damage produced by oxidized lipids. D-α-Tocopherylquinone binds to a liver cytosolic protein with a molecular mass of about 40 kDa. D-α-Tocopherylquinone binds to glurathione-S-transferase (GST) and can be transported to the site of metabolism or excreted in the bile. | ||||||||||||||||||||
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Rapanone | 99.93% | Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM. | ||||||||||||||||||||
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Homoembelin | Homoembelin is an antimicrobial compound and has the potential for MDR bacterial infection research. | |||||||||||||||||||||
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