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Cat. No.: HY-U00260

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CMI977

(Synonyms: LDP977)

CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.

For research use only. We do not sell to patients.

CAS No.: 175212-04-1
Formula: C₁₆H₁₉FN₂O₄
Molecular Weight:322.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

CMI977 Chemical Structure

CAS No.: 175212-04-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.

IC₅₀ & Target

5-LO

All Lipoxygenase Isoforms :

In Vitro

CMI977 is a potent 5-lipoxygenase (5-LO) inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI977, the S,S isomer is found to have the best biological activity and is selected for further development.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 175212-04-1
Molecular Weight 322.33
Formula C₁₆H₁₉FN₂O₄
SMILES

O=C(N)N(CCC#C[C@H]1O[C@H](COC2=CC=C(F)C=C2)CC1)O
Synonyms

LDP977
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiong Cai, et al. Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. Org. Proc. Res. Dev., 1999, 3 (1), pp 73-76.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CMI977

All Lipoxygenase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CMI977 Related Classifications

HY-U00260 Related Classifications