1. Autophagy
    Apoptosis
  2. Autophagy
    Ferroptosis
  3. PD146176

PD146176 (Synonyms: NSC168807)

Cat. No.: HY-103157 Purity: 98.04%
Handling Instructions

PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.

For research use only. We do not sell to patients.

PD146176 Chemical Structure

PD146176 Chemical Structure

CAS No. : 4079-26-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 385 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PD146176

  • Biological Activity

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  • References

  • Customer Review

Description

PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice[1][2][3].

IC50 & Target

Ki: 197 nM (Rabbit reticulocyte 15-LO)[1]
IC50: 0.54 μM[2]

In Vitro

In intact IC21 cells transfected with human 15-LO, PD146176 inhibits 13-HODE production with an IC50 of 0.81 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PD146176 (80 mg/kg; Chowing; 12 weeks) reverses cognitive impairment, brain amyloidosis, and Tau pathology by stimulating autophagy in aged triple transgenic mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triple transgenic (3xTg) mice[3]
Dosage: 80 mg/kg
Administration: Chowing; 12 weeks
Result: Significantly lower amyloid beta levels and deposition, less tau neuropathology, increased synaptic integrity, and autophagy activation.
Molecular Weight

237.32

Formula

C15H11NS

CAS No.
SMILES

C1(N2)=C(CSC3=CC=CC=C31)C4=C2C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (105.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2137 mL 21.0686 mL 42.1372 mL
5 mM 0.8427 mL 4.2137 mL 8.4274 mL
10 mM 0.4214 mL 2.1069 mL 4.2137 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (10.53 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (10.53 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.53 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥99.0%

References
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Product Name:
PD146176
Cat. No.:
HY-103157
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