30 Results for "

Erk/P38/Jnk Mapk pathway

" in MedChemExpress (MCE) Product Catalog:
Products (30)

30 Results for "Erk/P38/Jnk Mapk pathway" in MCE Product Catalog:

3
Asatone
Asatone
0 Images
3 Cited Publications
Cat. No.: HY-N6826
CAS No.: 38451-63-7
Category:  

Asarum sieboldii Miq. Natural Products Aristolochiaceae Extract Plants Disease Research Fields Inflammation/Immunology

Target:  

NF-κB

Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways .
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Oleuropein Aglycone
Oleuropein Aglycone
0 Images
1 Cited Publications
Cat. No.: HY-135115
CAS No.: 31773-95-2
Purity:  95.16%
Synonyms: 3,4-DHPEA-EA
Target:  

ERK AMPK NO Synthase JNK p38 MAPK Apoptosis

Research Areas:  

Neurological Disease Metabolic Disease Cancer

Oleuropein Aglycone (3,4-DHPEA-EA) is a secoiridoid that exerts antioxidant, anti-inflammatory, and anti-apoptotic effects by promoting ERK/AMPK/eNOS phosphorylation and inhibiting JNK/p38 MAPK and inflammation-related signaling pathways. Oleuropein Aglycone is used in research on acute kidney injury induced by ischemia-reperfusion injury, pleurisy, osteoporosis, Alzheimer's disease, neurodegenerative diseases, and triple-negative breast cancer .
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L-Quebrachitol
L-Quebrachitol
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Cat. No.: HY-N2375
CAS No.: 642-38-6
Category:  

Natural Products Metabolic Disease Plants Other Families Extract Disease Research Fields

Target:  

Wnt β-catenin p38 MAPK

L-Quebrachitol is a methoxy analog of inositol that can be isolated from plants. L-Quebrachitol has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway .
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Tetrahydropiperine
Tetrahydropiperine
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Cat. No.: HY-N4205
CAS No.: 23434-88-0
Category:  

Alkaloids Piperidine Alkaloids Piperaceae Extract Plants Disease Research Fields Piper nigrum Linn. Cancer

Target:  

Cytochrome P450

Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs, and an activator of the PI3K/Akt/mTOR pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke .
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Cenupatide
Cenupatide
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Cat. No.: HY-P1615
CAS No.: 1006388-38-0
Synonyms: UPARANT
Target:  

Transmembrane Glycoprotein Formyl Peptide Receptor (FPR) VEGFR Akt STAT JNK p38 MAPK ERK NF-κB Apoptosis Integrin

Research Areas:  

Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Cenupatide (UPARANT) is a uPAR and FPR antagonist with anti-angiogenic, anti-inflammatory, and vascular barrier regulatory activities, as well as high stability and resistance to enzymatic degradation in blood/plasma. Cenupatide blocks the uPAR-FPR interaction, reduces VEGF-induced phosphorylation levels of AKT, VEGFR-2, STAT3, JNK, p38 MAPK, ERK1/2, and NF-κB p65, and inhibits αvβ3 integrin activation. Cenupatide suppresses endothelial cell migration, invasion, tube formation, and angiogenic signaling pathways, restores tight junctions and blood-retinal barrier integrity, reduces pro-inflammatory marker levels, and inhibits apoptosis. Cenupatide reduces retinal neovascularization, renal fibrosis, and vascular leakage, and restores visual function in preclinical models. Cenupatide is applicable to research related to retinopathy, diabetic complications, ocular diseases, cancer, and inflammatory diseases .
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Physalin B
Physalin B
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Cat. No.: HY-N7695
CAS No.: 23133-56-4
Category:  

Ketones, Aldehydes, Acids Plants Other Families Extract Disease Research Fields Cancer

Target:  

Apoptosis NF-κB NOD-like Receptor (NLR) STAT PI3K Akt Hedgehog GSK-3 p38 MAPK ERK JNK Keap1-Nrf2 Reactive Oxygen Species (ROS) Autophagy

Physalin B is an orally active anti-inflammatory and anticancer agent. Physalin B can be isolated from Physalis alkekengi L. var. Franchetii. Physalin B inhibits the activation of the NF-κB, NLRP3 inflammasome, STAT3, PI3K/Akt and Hedgehog signaling pathways, regulates the phosphorylation levels of GSK-3β, p38 MAPK, ERK1/2 and JNK, and promotes the nuclear translocation of NRF2. Physalin B reduces the levels of pro-inflammatory cytokines and factors, induces mitochondrial reactive oxygen species (mito-ROS) production, Apoptosis, G2/M cell cycle arrest and incomplete Autophagy, alters cytoskeleton structure and alleviates oxidative stress. Physalin B reduces cancer cell viability, ameliorates liver and lung tissue damage and alleviates liver fibrosis. Physalin B can be used in research related to ulcerative colitis, breast cancer, acute lung injury, colon cancer, non-alcoholic steatohepatitis, liver fibrosis, lung cancer, pancreatic cancer, lymphoma, ovarian cancer, sarcoma and leukemia .
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Hellebrigenin
Hellebrigenin
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Cat. No.: HY-N6576
CAS No.: 465-90-7
Category:  

Animals Disease Research Fields Cancer Steroids

Target:  

p38 MAPK ERK JNK IAP PARP Apoptosis Caspase

Hellebrigenin is an inhibitor that selectively targets the MAPK signaling pathway (ERK, p38, JNK) and XIAP, and can inhibit Akt expression and phosphorylation. Hellebrigenin can activate endogenous apoptosis pathways (such as mitochondrial membrane potential disruption, Caspase family activation, PARP cleavage), downregulate anti-apoptotic proteins (Bcl-2, Bcl-xL) and upregulate pro-apoptotic proteins (Bax, Bak). Hellebrigenin can also induce DNA double-strand breaks to activate the ATM pathway. Hellebrigenin can inhibit tumor cell proliferation and clone formation, and is mainly used in the study of oral squamous cell carcinoma, liver cancer and other cancers .
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Loureirin D
Loureirin D
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Cat. No.: HY-N8189
CAS No.: 119425-91-1
Category:  

Phenols Polyphenols Plants Other Families Extract

Target:  

P2Y Receptor CD38 p38 MAPK JNK ERK MMP

Loureirin D is a selective P2Y12 receptor antagonist that penetrates the blood-brain barrier. Loureirin D inhibits the MAPK/JNK/ERK/p38 signaling pathway in microglia by acting on CD38, and inhibits ADP (HY-W010918)-induced platelet aggregation, MMP2/9-mediated tight junction disruption, and ischemia-related blood-brain barrier damage. Loureirin D protects endothelial cells from OGD-induced apoptosis. Loureirin D is used in studies of ischemic stroke and thrombosis .
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Mogroside III-E
Mogroside III-E
0 Images
Cat. No.: HY-N6928
CAS No.: 88901-37-5
Category:  

Triterpenes Terpenoids Metabolic Disease Cucurbitaceae Extract Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields

Target:  

Toll-like Receptor (TLR) ERK JNK p38 MAPK TGF-β Receptor TGF-beta/Smad Interleukin Related

Mogroside III-E is a cucurbitane-type triterpenoid glycoside extracted from Siraitia grosvenorii, and it is an orally active TLR4 inhibitor. Mogroside III-E downregulates the expression of TLR4 and MyD88, and blocks the phosphorylation of downstream ERK, JNK and p38 MAPK molecules; meanwhile, it inhibits TGF-β- or LPS-mediated transdifferentiation of primary pulmonary fibroblasts into myofibroblasts, reduces the content of fibrosis markers such as hydroxyproline, suppresses the pro-fibrotic TGF-β/Smad signaling pathway, and downregulates the levels of inflammatory factors MPO and IL-1β. Mogroside III-E alleviates Bleomycin (HY-108345)-induced pulmonary collagen deposition and inflammatory infiltration in mice. Mogroside III-E can be used in studies related to idiopathic pulmonary fibrosis .
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Ganomycin I
Ganomycin I
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Cat. No.: HY-N10076
CAS No.: 1191255-15-8
Category:  

Microorganisms Phenols Polyphenols

Target:  

HMG-CoA Reductase (HMGCR) Glycosidase HIV Protease

Ganomycin I is a non-competitive dual inhibitor of α-glucosidase and HMG-CoA reductase, with IC50 values of 0.3 μM and 12.3 μM, respectively. Ganomycin I inhibits HIV-1 protease, with an IC50 of 7.5 μg/mL. Ganomycin I also suppresses RANKL-induced osteoclast differentiation and bone resorption by inhibiting the activation of ERK, JNK and p38 MAPK, as well as downregulating the c-Fos/NFATc1 signaling pathway. Ganomycin I exhibits antibacterial activity against Gram-positive bacteria, and shows weak activity against Mycobacterium tuberculosis H37Ra. It can be used in research related to metabolic diseases, bone metabolism and anti-infection .
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Satratoxin H
Satratoxin H
0 Images
Cat. No.: HY-123647
CAS No.: 53126-64-0
Category:  

Natural Products Microorganisms

Target:  

Endogenous Metabolite p38 MAPK JNK Caspase PARP ERK Apoptosis Reactive Oxygen Species (ROS)

Satratoxin H is a toxic metabolite of Stachybotrys atra. Satratoxin H induces caspase-3 and PARP cleavage via p38 MAPK and JNK pathways, stimulates JNK, ERK, and p38 MAPK phosphorylation, and activates JNK and p38 MAPK in a glutathione-sensitive manner. Satratoxin H induces DNA double-stranded breaks, apoptotic body formation, intracellular reactive oxygen species generation, and endoplasmic reticulum stress via ATF6, PERK, and IRE1 pathways. Satratoxin H can be used for the research of central nervous system disorders and melanoma .
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HVF18-a3-d
HVF18-a3-d
0 Images
Cat. No.: HY-P11250
Target:  

Bacterial NO Synthase Interleukin Related Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) ERK JNK p38 MAPK

Research Areas:  

Infection Inflammation/Immunology

HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-α and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects .
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Limocitrin
Limocitrin
0 Images
Cat. No.: HY-119539
CAS No.: 489-33-8
Category:  

Flavonols Flavonoids Plants Platanaceae Extract Platanus orientalis L.

Target:  

Akt JNK p38 MAPK ERK Caspase Apoptosis

Limocitrin is a flavonol glycoside. Limocitrin inhibits AKT phosphorylation and JNK phosphorylation, upregulates p38 phosphorylation, and inhibits ERK1/2 phosphorylation, thereby blocking MAPK signaling. Limocitrin induces Apoptosis through the mitochondrial pathway, death receptor-mediated signaling, Caspase activation, and G2/M cell cycle arrest. Limocitrin possesses anti-inflammatory and anticancer properties . Limocitrin can be used for research on oral squamous cell carcinoma and chronic myeloid leukemia .
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Tetrahydropiperine (Standard)
Tetrahydropiperine (Standard)
0 Images
Cat. No.: HY-N4205R
CAS No.: 23434-88-0
Category:  

Alkaloids Piperidine Alkaloids Piperaceae Extract Plants Piper nigrum Linn.

Target:  

Reference Standards Cytochrome P450

Tetrahydropiperine (Standard) is the analytical standard of Tetrahydropiperine (HY-N4205). This product is intended for research and analytical applications. Tetrahydropiperine is an orally effective, selective inhibitor of NF-κB and MAPKs, and an activator of the PI3K/Akt/mTOR pathway. Tetrahydropiperine reduces the production of pro-inflammatory cytokines such as TNF-α, IL-6, and nitric oxide (NO) by inhibiting the nuclear translocation of NF-κB and the phosphorylation of MAPKs such as ERK, JNK, and p38. At the same time, Tetrahydropiperine inhibits excessive autophagy by activating the PI3K/Akt/mTOR pathway, protecting neurons from oxidative damage. Tetrahydropiperine has anti-inflammatory, anti-apoptotic, and neuroprotective effects, and is mainly used in the study of inflammatory diseases (such as endotoxemia, arthritis) and neurological diseases such as ischemic stroke .
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Pratol
Pratol
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Cat. No.: HY-N8719
CAS No.: 487-24-1
Synonyms: 7-Hydroxy-4'-methoxyflavone
Category:  

Flavonoids Flavones Leguminosae Extract Plants Trifolium pratense Linn.

Target:  

NF-κB PGE synthase TNF Receptor Interleukin Related p38 MAPK JNK ERK Akt PKA Microphthalmia Associated Transcription Factor (MITF) TRP Channel NO Synthase COX IKK

Pratol (7-Hydroxy-4'-methoxyflavone) is an NF-κB inhibitor. Pratol also inhibits NO, PGE2, TNF-α, IL-1β, and IL-6 production. Pratol increases the phosphorylation of p38 MAPK, JNK, and ERK, decreases AKT phosphorylation, and upregulates MITF, tyrosinase, TRP-1, and TRP-2 through a PKA-dependent signaling pathway. Pratol reduces iNOS and COX-2 protein expression, inhibits p65 phosphorylation, and protects IκBα from degradation, thereby inhibiting NF-κB nuclear translocation. Pratol can be used in research on hypopigmentary disorders, inflammatory diseases, cervical cancer, and colon cancer .
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MAPK-IN-3
MAPK-IN-3
0 Images
Cat. No.: HY-169412
CAS No.: 2848599-79-9
Target:  

MDM-2/p53 CDK Caspase Bcl-2 Family Reactive Oxygen Species (ROS) p38 MAPK ERK JNK

Research Areas:  

Cancer

MAPK-IN-3 (Compound 4a) is an anti-proliferative agent that shows particularly strong inhibitory effects on KYSE 30, HCT 116, and HGC 27, with IC50 values of 0.57 μM, 3.27 μM, and 2.28 μM, respectively. MAPK-IN-3 blocks the cell cycle via a p53-dependent mechanism and induces cell apoptosis through a p53-independent mechanism. MAPK-IN-3 downregulates the expression of cell cycle-related proteins like Cyclin D1 and cyclin B1, upregulates pro-apoptotic proteins such as cleaved PARP, cleaved caspase-7, and cleaved caspase-9, and reduces the expression of anti-apoptotic proteins like Bcl-2. Additionally, MAPK-IN-3 increases the intracellular level of ROS in KYSE 30 cells and upregulates the expression of members of the MAPK signaling pathway associated with ROS, such as p-ERK, p-p38 and p-JNK .
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L-Quebrachitol (Standard)
L-Quebrachitol (Standard)
0 Images
Cat. No.: HY-N2375R
CAS No.: 642-38-6
Category:  

Natural Products Plants Other Families Extract

Target:  

Reference Standards Wnt β-catenin p38 MAPK

L-Quebrachitol is a methoxy analog of inositol that can be isolated from plants. L-Quebrachitol has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway .
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Cm-CATH2
Cm-CATH2
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Cat. No.: HY-P11242
Target:  

Bacterial NF-κB p38 MAPK JNK ERK TNF Receptor Interleukin Related

Research Areas:  

Infection

Cm-CATH2 is an antimicrobial peptide discovered from Chelonia mydas. Cm-CATH2 has a potent, broad-spectrum and rapid bactericidal ability by rapidly destroying the integrity of bacterial cell membranes. It shows strong activity against Gram-positive bacteria (such as VREF, Staphylococcus aureus), Gram-negative bacteria (such as Escherichia coli, Klebsiella pneumoniae), and fungi (such as Candida albicans) with MICs ranges from 1.17 to 18.75 μg/mL. Cm-CATH2 is also effective against various aquatic pathogenic bacteria. Cm-CATH2 not only inhibits biofilm formation but can also remove the formed biofilms. Cm-CATH2 has immunomodulatory functions and chemotactic effects on immune cells, and can inhibit the production of pro-inflammatory cytokines by macrophages stimulated by LPS (HY-D1056). Cm-CATH2 prevents the activation of NF-κB by inhibiting the degradation of IκBα, and also inhibits the phosphorylation of MAPK signaling pathways (p38, JNK, ERK). Cm-CATH2 demonstrates strong anti-infective ability in mouse peritonitis models and pneumonia models .
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Oxonantenine
Oxonantenine
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Cat. No.: HY-N19654
CAS No.: 15358-38-0
Category:  

Alkaloids Nandina domestica Thunb. Quinoline Alkaloids Plants Berberidaceae Extract

Target:  

NF-κB p38 MAPK ERK JNK

Oxonantenine is an isoquinoline alkaloid isolated from the seeds of Nandina domestica that exhibits cytotoxicity against cancer cells. Oxonantenine binds to proteins associated with the MAPK and NF-κB signaling pathways, including JUN, MAPK1, p38, MAPK3, ERK, JNK3, and p65. Oxonantenine is one of the main components of Fangji Huangqi Tang. Oxonantenine can be used in studies related to non-small cell lung cancer and rheumatoid arthritis .
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Evariquinone
Evariquinone
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Cat. No.: HY-118817
CAS No.: 594860-23-8
Category:  

Quinones Microorganisms Anthraquinones

Target:  

Free Radical Scavengers Reactive Oxygen Species (ROS) Calcium Channel JNK ERK p38 MAPK Apoptosis

Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK, ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca 2+, thereby reducing neuronal apoptosis. Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.) .
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