2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Neuronal Signaling MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. Reactive Oxygen Species (ROS) Calcium Channel JNK ERK p38 MAPK Apoptosis
  4. Evariquinone

Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK, ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca2+, thereby reducing neuronal apoptosis. Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.).

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Evariquinone

Evariquinone Chemical Structure

CAS No. : 594860-23-8

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Evariquinone Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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ERK ERK1 ERK2 ERK5 ERK8

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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Description

Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK, ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca2+, thereby reducing neuronal apoptosis. Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.)[1].

IC50 & Target[1]

ERK1

 

ERK2

 

In Vitro

Evariquinone (10-100 μM) shows concentration-dependent DPPH radical scavenging activity with an IC50 of 42.2 μM and a maximum activity of 70 ± 1.78% at 100 μM[1].
Evariquinone (12-100 μM; 24 h) provides concentration-dependent neuroprotection against 5 mM glutamate-induced cytotoxicity in HT22 cells, restoring cell viability to near control levels at 50 and 100 μM[1].
Evariquinone (50, 100 μM; 8 h) significantly inhibits 5 mM glutamate-induced intracellular ROS accumulation in HT22 cells[1].
Evariquinone (50, 100 μM; 8 h) significantly blocks 5 mM glutamate-induced intracellular Ca2+ influx in HT22 cells, reducing fluorescence intensity to near control levels at 100 μM[1].
Evariquinone (50, 100 μM; 8 h) significantly inhibits 5 mM glutamate-induced phosphorylation of JNK, ERK1/2, and p38 in HT22 cells[1].
Evariquinone (50, 100 μM; 10 h) strongly attenuates 5 mM glutamate-mediated apoptotic cell death in HT22 cells, reducing the percentage of apoptotic cells to ~18% and ~14%, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Evariquinone Related Antibodies

Cell Viability Assay[1]

Cell Line: immortalized murine hippocampal HT22 neuronal cells
Concentration: 12-100 μM
Incubation Time: 24 h
Result: Significantly increased cell viability in a concentration-dependent manner; 12 μM increased cell viability to ~50%, 25 μM to ~80%, 50 μM to ~100%, and 100 μM to ~100% relative to control cells.

Western Blot Analysis[1]

Cell Line: HT22 cells
Concentration: 50, 100 μM
Incubation Time: 8 h
Result: Significantly reduced glutamate-induced phosphorylation of JNK, ERK1/2, and p38; quantitative analysis showed marked decreases in phosphorylated protein levels relative to the glutamate-only treated group.

Apoptosis Analysis[1]

Cell Line: HT22 cells
Concentration: 50, 100 μM
Incubation Time: 10 h
Result: Significantly reduced the percentage of annexin V-positive apoptotic cells; glutamate treatment increased apoptotic cells to ~60%, while 50 μM reduced this to ~18% and 100 μM to ~14%.
Molecular Weight

300.26

Formula

C16H12O6
CAS No.
SMILES

O=C1C2=C(C(C3=CC(O)=C(C(O)=C13)O)=O)C=C(C=C2OC)C
Structure Classification
Initial Source

endosymbiotic Emericella variecolor CLB38
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Evariquinone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Evariquinone594860-23-8Reactive Oxygen Species (ROS)Calcium ChannelJNKERKp38 MAPKApoptosisCa2+ channelsCa channelsc-Jun N-terminal kinaseExtracellular signal regulated kinasesmitogen-activated protein kinasereactive oxygen speciescalcium ionparkinson’s diseaseextracellular signal-regulated kinase 1/2HT22 cellsapoptotic cell deathalzheimer’s diseasep38 mitogen-activated protein kinaseInhibitorinhibitorinhibit

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