2. Anti-infection MAPK/ERK Pathway NF-κB Cell Cycle/DNA Damage
  3. Bacterial p38 MAPK NF-κB PERK JNK
  4. Gy-CATH

Gy-CATH is an anionic antimicrobial peptide. Gy-CATH activates MAPK and NF-κB signaling pathways (elevated levels of phospho-ERK, -p38, -JNK, -p65, and -IκBα). Gy-CATH upregulates the expression levels of three physiological anticoagulant pathways. Gy-CATH inhibits ADP-, Collagen-, and PMA-induced platelet aggregation. Gy-CATH has no direct antimicrobial activity, but shows significant preventive abilities against mice infected with Staphylococcus aureus, Escherichia coli, and Methicillin (HY-121544)-resistant Staphylococcus aureus. Gy-CATH exhibits potent immunomodulatory activity, enhancing macrophage-and neutrophil-mediated bactericidal functions. Gy-CATH significantly reduces the extent of pulmonary fibrin deposition and prevents thrombosis in mice.

For research use only. We do not sell to patients.

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Gy-CATH

Gy-CATH Chemical Structure

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Gy-CATH Related Antibodies

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Description

Gy-CATH is an anionic antimicrobial peptide. Gy-CATH activates MAPK and NF-κB signaling pathways (elevated levels of phospho-ERK, -p38, -JNK, -p65, and -IκBα). Gy-CATH upregulates the expression levels of three physiological anticoagulant pathways. Gy-CATH inhibits ADP-, Collagen-, and PMA-induced platelet aggregation. Gy-CATH has no direct antimicrobial activity, but shows significant preventive abilities against mice infected with Staphylococcus aureus, Escherichia coli, and Methicillin (HY-121544)-resistant Staphylococcus aureus. Gy-CATH exhibits potent immunomodulatory activity, enhancing macrophage-and neutrophil-mediated bactericidal functions. Gy-CATH significantly reduces the extent of pulmonary fibrin deposition and prevents thrombosis in mice[1][2].

Molecular Weight

2701.03

Formula

C118H186N28O40S2
Sequence

Ala-Glu-Glu-Glu-Ala-Glu-Lys-Thr-His-Lys-Thr-Glu-Cys-Leu-Glu-Cys-Ile-Phe-Thr-Leu-Leu-Pro-Pro-Ala (Disulfide bridge: Cys13-Cys16)
Sequence Shortening

AEEEAEKTHKTECLECIFTLLPPA (Disulfide bridge: Cys13-Cys16)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Gy-CATH Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gy-CATHBacterialp38 MAPKNF-κBPERKJNKNuclear factor-κBNuclear factor-kappaBProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasec-Jun N-terminal kinaseantimicrobialthrombosismiceInhibitorinhibitorinhibit

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