Arnicolide B
Arnicolide B is a sesquiterpene lactone. Arnicolide B is isolated from Centipeda minima. Arnicolide B inhibits the phosphorylation of ERK, JNK and p38 proteins in the MAPK signaling pathway. Arnicolide B reduces the production of inflammatory mediators NO, PGE2 and IL-6. Arnicolide B downregulates the overexpression of inflammatory proteins iNOS and COX-2. Arnicolide B has no effect on IκB-α degradation or NF-κB pathway activation. Arnicolide B is applicable to inflammation-related research.
For research use only. We do not sell to patients.
- CAS No.: 34532-66-6
- Formula: C20H28O5
- Molecular Weight:348.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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iNOS |
COX-2 |
IL-6 |
Arnicolide B (0.78-100 μM; 24 h) shows no cytotoxicity against RAW 264.7 cells at concentrations ≤6.25 μM[1].
Arnicolide B (0.78-6.25 μM; 24 h) dose-dependently inhibits LPS-induced excessive NO production in RAW 264.7 macrophages[1].
Arnicolide B (0.78-6.25 μM; 24 h) dose-dependently downregulates LPS-induced overexpression of iNOS and COX-2 in RAW 264.7 macrophages[1].
Arnicolide B (0.78-6.25 μM; 10 min) exerts no significant inhibitory effect on LPS-induced IκB-α degradation in RAW 264.7 macrophages, indicating that it has no impact on the NF-κB pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-activated mouse monocyte-macrophage RAW 264.7 cells
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Concentration:0.78-6.25 μM
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Incubation Time:24 h
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Result:Reduced LPS-induced iNOS expression at 0.78 μM.
Reduced LPS-induced iNOS expression at 1.56 μM.
Reduced LPS-induced iNOS expression at 3.12 μM.
Reduced LPS-induced iNOS expression 6.25 μM.
Reduced LPS-induced COX-2 expression.
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Cell Line:LPS-activated mouse monocyte-macrophage RAW 264.7 cells
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Concentration:0.78-6.25 μM
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Incubation Time:10 min
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Result:Did not alter LPS-induced IκB-α degradation, with IκB-α expression remaining at ~15-20% relative to β-actin, similar to the LPS-only group.
Chemical Information
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CAS No. 34532-66-6
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Molecular Weight 348.44
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Formula C20H28O5
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SMILES
O(C(CC(C)C)=O)[C@H]1[C@]2([C@@](C[C@@H](C)[C@]3([C@@]1(C)C(=O)C=C3)[H])(OC(=O)[C@H]2C)[H])[H]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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