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Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .
Nrf2-IN-1 is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML) .
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active .
AChE/Nrf2 modulator 1 is an orally active acetylcholinesterase (AChE)/nuclear factor erythroid 2-related factor 2 (Nrf2) modulator. AChE/Nrf2 modulator 1 has Nrf2 inductive activity and AChE inhibitory activity for eeAChE and hAChE with IC50 values of 0.07 μM and 0.38 μM, respectively. AChE/Nrf2 modulator 1 can be used for the research of Alzheimer's disease .
Dimethyl fumarate-d6 is a deuterium labeled Dimethyl fumarate. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression[1][2][3][4][5][6].
Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners .
cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .
Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation .
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active .
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .
Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners .
cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .
AHSP protein, a chaperone in erythroid cell development, safeguards alpha-hemoglobin, preventing harmful aggregation and precipitation. Crucial for alpha-hemoglobin stability, it modulates conditions linked to alpha-hemoglobin excess, like beta-thalassemia. AHSP forms a selective heterodimer with free alpha-hemoglobin, not binding to beta-hemoglobin or alpha(2)beta(2) hemoglobin A. This interaction prevents detrimental interactions, ensuring the proper hemoglobin component balance in erythropoiesis. AHSP Protein, Human is the recombinant human-derived AHSP protein, expressed by E. coli, with tag free. The total length of AHSP Protein, Human is 102 a.a., with molecular weight of ~12 KDa.
ERMAP protein potentially serves as a cell-adhesion or receptor molecule in erythroid cells, suggesting involvement in crucial interactions or signaling events. The precise mechanisms, ligands, and broader implications of ERMAP's activity in erythroid cell biology require further investigation. Unraveling ERMAP's function may provide insights into its significance in hematopoiesis and related physiological processes. ERMAP Protein, Human (HEK293, His) is the recombinant human-derived ERMAP protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ERMAP Protein, Human (HEK293, His) is 126 a.a., with molecular weight of ~16.0 kDa.
The INHBA protein plays a key role in regulating pituitary function by regulating follicle-stimulating hormone secretion together with activin. Its broad effects span a variety of physiological processes, including hormone secretion, germ cell development, erythrocyte differentiation, insulin secretion, nerve cell survival, embryonic development, and bone growth, depending on unique subunit composition. Animal-Free Activin A Protein, Human/Mouse/Rat (His) is the recombinant human, rat, mouse-derived animal-FreeActivin A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free Activin A Protein, Human/Mouse/Rat (His) is 116 a.a., with molecular weight of ~13.9 kDa.
TIMP-1 is a metalloproteinase inhibitor that irreversibly inactivates collagenase and other metalloproteinases by binding to their catalytic zinc cofactor. It regulates MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16 and affects cellular processes such as differentiation, migration and cell death. TIMP-1 Protein, Mouse (HEK293) is the recombinant mouse-derived TIMP-1 protein, expressed by HEK293 , with tag free. The total length of TIMP-1 Protein, Mouse (HEK293) is 181 a.a., with molecular weight of ~26.0 kDa.
The TIMP-1 protein forms a one-to-one complex with the target metalloprotease, irreversibly inactivating it by binding to the catalytic zinc cofactor. It inhibits multiple MMPs, activates cell signaling through CD63 and ITGB1, and interacts with MMP1, MMP3, MMP10, and MMP13. TIMP-1 Protein, Human (184a.a, HEK293, His) is the recombinant human-derived TIMP-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of TIMP-1 Protein, Human (184a.a, HEK293, His) is 184 a.a., with molecular weight of ~27.0 kDa.
ALAS2 Protein catalyzes PLP-dependent condensation of succinyl-CoA and glycine, producing aminolevulinic acid (ALA) with CoA and CO2 by-products. It significantly contributes to heme formation in erythropoiesis, with catalytic activity reaching 75-85% of isoform 1. ALAS2 Protein, Human (His) is the recombinant human-derived ALAS2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ALAS2 Protein, Human (His) is 538 a.a., with molecular weight of ~63.5 kDa.
The NFE2L2 protein is a key transcription factor that activates cytoprotective genes in response to oxidative stress by binding to the antioxidant response element (ARE). Normally, the BCR(KEAP1) complex degrades NFE2L2 in the cytoplasm. NFE2L2 Protein, Human (P.pastoris, His) is the recombinant human-derived NFE2L2 protein, expressed by P. pastoris , with N-His labeled tag. The total length of NFE2L2 Protein, Human (P.pastoris, His) is 605 a.a., with molecular weight of ~70.0 kDa.
Dimethyl fumarate-d6 is a deuterium labeled Dimethyl fumarate. Dimethyl fumarate is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator and induces upregulation of antioxidant gene expression[1][2][3][4][5][6].
Nrf2 Antibody(YA895) is an unconjugated, approximately 68 kDa, rabbit-derived, anti-Nrf2(YA895) monoclonal antibody. Nrf2 Antibody(YA895) can be used for: WB, IHC-P, ICC/IF, IP, ChIP expriments in human, mouse background without labeling.
Phospho-Nrf2 (Ser40) Antibody (YA168) is a non-conjugated and Rabbit origined monoclonal antibody about 68 kDa, targeting to Phospho-Nrf2(S40). It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human.
Phospho-Nrf2 (Ser40) Antibody (YA169) is a non-conjugated and Rabbit origined monoclonal antibody about 68 kDa, targeting to Phospho-Nrf2 (Ser40). It can be used for WB,IHC-P assays with tag free, in the background of Human.
Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 Erythroid potentiating activity collagenase inhibitor.
WB; ELISA; IHC-P; IHC-F; IF
Human, Mouse, Rabbit(predicted: Rat, Dog, Pig, Cow, Sheep)
TIMP-1 Antibody is an unconjugated, approximately 21 kDa, rabbit-derived, anti-TIMP-1 polyclonal antibody. TIMP-1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rabbit, and predicted: rat, dog, pig, cow, sheep background without labeling.
