cis-Vaccenic acid

Name: cis-Vaccenic acid
Brand: MedChemExpress
SKU: HY-113427A
Rating: 4.5 (1 reviews)

Cat. No.: HY-113427A Purity: 99.91%: Data Sheet
COA

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cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate, acts a potential fetal hemoglobin inducer.

For research use only. We do not sell to patients.

cis-Vaccenic acid Chemical Structure

CAS No. : 506-17-2

Size	Stock	Quantity
Solvent
25 mg (1.77 M * 0.05 mL in Ethanol)	In-stock	Estimated Time of Arrival: December 31
Solvent
50 mg (1.77 M * 0.1 mL in Ethanol)	In-stock	Estimated Time of Arrival: December 31
Solvent
100 mg (1.77 M * 0.2 mL in Ethanol)	In-stock	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate^[1], acts a potential fetal hemoglobin inducer^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	16 μM Compound: vaccenic acid	Inhibition of telomerase extracted from human K562 cells preincubated for 10 mins followed by dNTPs and telomerase substrate primer TS-A addition measured after 30 mins by TRAP assay Inhibition of telomerase extracted from human K562 cells preincubated for 10 mins followed by dNTPs and telomerase substrate primer TS-A addition measured after 30 mins by TRAP assay	10.1039/C0MD00241K

In Vitro

cis-Vaccenic acid (CVA) (50 μM, 70 μM and 100 μM) induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells^[2]. cis-Vaccenic acid (50 μM) also increased the percentage of benzidine positive JK-1 cell^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay^[2]

Cell Line:	K562 cells
Concentration:	50 μM, 70 μM and 100 μM
Incubation Time:	48 and 120 hours
Result:	Induced differentiation appeared to be concentration dependent in K562 cells with 50 μM CVA being the most effective concentration with more than 20% of the K562 cells showing positive for Benzidine stain after 48 h of incubation with CVA.

Molecular Weight

282.46

Formula

C₁₈H₃₄O₂

CAS No.

506-17-2

Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCCC/C=C\CCCCCCCCCC(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Rhodopseudomonas capsulate

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: 99.91%

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Data Sheet (261 KB) SDS (393 KB)

COA (237 KB) RP-HPLC (117 KB)

Handling Instructions (2659 KB)

References

[1]. H Hirotani, et al. Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols. FEMS Microbiol Lett. 1991 Jan 1;61(1):13-7. [Content Brief]

[2]. Idowu A Aimola, et al. Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells. Eur J Pharmacol. 2016 Apr 5;776:9-18. [Content Brief]