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Art. -Nr.: HY-P3598

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Substance P(1-4)

Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation.

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CAS. Nr.: 57468-16-3
Formel: C₂₂H₄₀N₈O₅
Molecular Weight:496.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Substance P(1-4) Chemical Structure

CAS. Nr.: 57468-16-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation^[1].

Alle Neurokinin Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Substance P(1-4) (0.1 nM-1 μM) inhibits endogenous erythroid colony (EEC) formation in PV bone marrow cultures^[1].
Substance P(1-4) (0.1 nM-1 μM; CD36+/GpA- cells) decreases of erythroid colony numbers of 47% and inhibits proliferation of PV CD36+/GpA- cells of 30 %^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Cell Viability Assay^[1]

View Protocol

Cell Line:

PV CD36+/GpA- cells
Concentration:

0.1 nM-1 μM
Incubation Time:

2 days
Result:

Inhibited proliferation of PV CD36+/GpA- cells of 30 %.

Apoptosis Analysis^[1]

View Protocol

Cell Line:

PV CD36+/GpA- cells
Concentration:

10 nM
Incubation Time:

2 days
Result:

Increased the percentage of cell death of 27.3%.

Chemical Information

CAS. Nr. 57468-16-3
Molecular Weight 496.60
Formel C₂₂H₄₀N₈O₅
Sequence Shortening

RPKP
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Le Gall C, et, al. Inhibitory effect of the substance P and its derivative on erythropoietin-independent growth of erythroid progenitors in polycythemia vera. Leuk Res. 2008 May;32(5):743-54. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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