NEAS/alpha-Fodrin Antibody (YA3347)
(Synonyms: SPTAN1; NEAS; SPTA2; Spectrin alpha chain; non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin; non-erythroid alpha subunit)NEAS/alpha-Fodrin Antibody (YA3347) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NEAS/alpha-Fodrin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:10 |
Product Details
NEAS/alpha-Fodrin Antibody (YA3347) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NEAS/alpha-Fodrin.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 150,285 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 285 kDa
Entrez Gene: 6709 Human ; 20740 Mouse ; 64159 Rat
SwissProt: Q13813 Human ; P16546 Mouse ; P16086 Rat
OMIM: 613477 Human
A synthesized peptide derived from human Alpha Fodrin aa50-105/2472.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NEAS/alpha-Fodrin is a Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane
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Subcellular Localization
Cytoplasm, cytoskeleton; Cytoplasm, cell cortex
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Expression
Induction:Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts (via C-terminal spectrin repeats) with TRPC4. Interacts with CALM and EMD. Interacts with isoform 1 of ACP1. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. Interacts with SHANK3 (via ANK repeats) . Interacts with CLN3; this interaction regulates the fodrin localization at the plasma membrane (Probable) -
Isoforms & Post-Translational Modification
Q13813 has 3 isomers: Q13813-1: 284539 Da (predicted); Q13813-2: 285094 Da (predicted); Q13813-3: 282282 Da (predicted).
Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro -
Subunit
Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts (via C-terminal spectrin repeats) with TRPC4. Interacts with CALM and EMD. Interacts with isoform 1 of ACP1. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. Interacts with SHANK3 (via ANK repeats). Interacts with CLN3; this interaction regulates the fodrin localization at the plasma membrane (Probable)
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SwissProt ID
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Synonyms
SPTAN1; NEAS; SPTA2; Spectrin alpha chain; non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin; non-erythroid alpha subunit
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Research Field
Signal Transduction
Documentation
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