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Results for "

Gyrase+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

28

Inhibitors & Agonists

1

Peptides

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0425
    Novobiocin
    10+ Cited Publications

    Albamycin; Cathomycin

    		 Antibiotic DNA/RNA Synthesis HSP Apoptosis Bacterial Orthopoxvirus Infection Cancer
    Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity .
    Novobiocin
  • HY-B0425A
    Novobiocin sodium
    10+ Cited Publications

    Albamycin sodium; Cathomycin sodium

    		 Bacterial Antibiotic Orthopoxvirus Apoptosis DNA/RNA Synthesis HSP Infection Cancer
    Novobiocin (Albamycin) sodium is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity .
    Novobiocin sodium
  • HY-136638
    ML328

    		DNA/RNA Synthesis Bacterial Infection
    ML328 is a selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC50 values of 26 and 5.1 μM, respectively. ML328 is a gyrase inhibitor. ML328 strongly inhibits the growth of E. coli in the presence of phage. ML328 can be used for the research of bacterial infection .
    ML328
  • HY-125631
    Cyclothialidine

    Ro 09-1437

    		 DNA/RNA Synthesis Bacterial Infection
    Cyclothialidine ( Ro 09-1437) is a potent DNA gyrase inhibitor isolated from Streptomyces filipinensisNR0484 .
    Cyclothialidine
  • HY-P3473
    Evybactin

    		Bacterial DNA/RNA Synthesis Infection
    Evybactin is a DNA gyrase inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity .
    Evybactin
  • HY-149851
    DNA Gyrase-IN-7

    		DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-7 (compound 6d) is a novel Microbial DNA-Gyrase inhibitor .
    DNA Gyrase-IN-7
  • HY-169384
    Antimycobacterial agent-10

    		Bacterial Infection
    Antimycobacterial agent-10 (compound 5) is a DNA gyrase inhibitor with anti-bacterial actiity (IC50=96 nM, M. tuberculosis gyrase).
    Antimycobacterial agent-10
  • HY-149294
    DNA Gyrase-IN-8

    		DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-8 is a potent DNA gyrase inhibitor with an IC50 value of 8.45 µM. DNA Gyrase-IN-8 shows antimicrobial activity .
    DNA Gyrase-IN-8
  • HY-19951A
    A-867191 hydrochloride

    		Bacterial Infection
    A-867191 hydrochloride is a 2-pyridone DNA gyrase inhibitor. A-867191 hydrochloride has antibacterial activity. A-867191 hydrochloride can be used for research on infections .
    A-867191 hydrochloride
  • HY-161756
    DNA Gyrase-IN-10

    		DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-10 is a potent DNA gyrase inhibitor with potent antibacterial effects. DNA Gyrase-IN-10 has inhibitory effects on both Gram-positive and Gram-negative bacteria .
    DNA Gyrase-IN-10
  • HY-143484
    844-TFM

    		Bacterial Infection
    844-TFM is a NBTI (novel bacterial topoisomerase inhibitor) DNA gyrase inhibitor, with an IC50 of 1.5 μM. 844-TFM exhibits bactericidal properties against M. abscessus .
    844-TFM
  • HY-121782
    A 65281

    		Bacterial DNA/RNA Synthesis Infection
    A 65281 is a potent DNA gyrase inhibitor with an IC50 value of 0.1 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II. A 65281 inhibits P4 DNA unknotting with an IC50 value of 8 µg/mL .
    A 65281
  • HY-147988
    DNA Gyrase-IN-5

    		DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-5 (Compound 8I-w) is a potent DNA gyrase inhibitor with an IC50 of 0.10 μM. DNA Gyrase-IN-5 shows antibacterial activities against wild type and drug-resistant strains .
    DNA Gyrase-IN-5
  • HY-168511
    DNA Gyrase-IN-13

    		DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-13 (compound 1b) is a DNA Gyrase inhibitor. DNA Gyrase-IN-13 has antibacterial activity. DNA Gyrase-IN-13 has an IC50 value of 1.81 μM for Staphylococcus aureus DNA gyrase .
    DNA Gyrase-IN-13
  • HY-143482
    MMV688844

    		Bacterial DNA/RNA Synthesis Infection
    MMV688844 is a potent Mycobacterium abscessus (Mabs) DNA Gyrase inhibitor with an IC50 value of 2 μM. MMV688844 has bactericidal properties against Mabs bamboo with a MIC50 of 12 μM. MMV688844 can be used for researching anti-bacteria .
    MMV688844
  • HY-169105
    DNA Gyrase-IN-12

    		DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-12 (Compound 6d) is a DNA gyrase inhibitor. DNA Gyrase-IN-12 has Antibacterial activity and MIC value of vancomycin-intermediate S. aureus (VISA) and Enterococcus faecalis strains is between 0.031 and 0.0625 μg/mL .
    DNA Gyrase-IN-12
  • HY-143483
    NBTIs-IN-5

    		Bacterial Infection
    NBTIs-IN-5 (Compound 5r) is a NBTI (Novel Bacterial Topoisomerase Inhibitor) DNA gyrase inhibitor with an IC50 of 1.5 μM against Mycobacterium abscessus (Mabs) DNA gyrase. NBTIs-IN-5 inhibits Mabs bamboo bacterial growth with an MIC90 of 0.4 μM .
    NBTIs-IN-5
  • HY-109785A
    (R)-Gyramide A hydrochloride

    		Bacterial Infection
    (R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.
    (R)-Gyramide A hydrochloride
  • HY-147000
    DNA Gyrase-IN-1

    		Bacterial DNA/RNA Synthesis Infection
    DNA Gyrase-IN-1 (compound 42) is a potent and selective DNA gyrase inhibitor with an IC50 value of 2.6 µM. DNA Gyrase-IN-1 has high inhibitory activity against Mycobacterium tuberculosis (Mtb) with MIC of 0.49 µM. DNA Gyrase-IN-1 can be used for researching tuberculosis .
    DNA Gyrase-IN-1
  • HY-147948
    DNA Gyrase-IN-4

    		DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC50 of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively .
    DNA Gyrase-IN-4
  • HY-150044
    Type II topoisomerase inhibitor 1

    		DNA/RNA Synthesis Topoisomerase Bacterial Infection
    Type II topoisomerase inhibitor 1 is a potent and selective E. coli DNA gyrase inhibitor (IC50: 1.7 nM), and forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity (IC50: 0.98 μM). Type II topoisomerase inhibitor 1 can be used in the research of antibacterial area .
    Type II topoisomerase inhibitor 1
  • HY-B0425R
    Novobiocin (Standard)

    Albamycin (Standard); Cathomycin (Standard)

    		 Antibiotic DNA/RNA Synthesis HSP Apoptosis Bacterial Orthopoxvirus Reference Standards Infection Cancer
    Novobiocin (Standard) is the analytical standard of Novobiocin. This product is intended for research and analytical applications. Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity .
    Novobiocin (Standard)
  • HY-172962
    DNA Gyrase-IN-17

    		DNA/RNA Synthesis Bacterial Infection
    DNA Gyrase-IN-17 (Compound 5C) is a DNA Gyrase inhibitor. DNA Gyrase-IN-17 exhibits significant antibacterial activity against a variety of Gram-positive and Gram-negative strains (such as Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, etc.), with a MIC value of 62.5 μg/mL. DNA Gyrase-IN-17 interferes with DNA replication by inhibiting bacterial DNA gyrase. DNA Gyrase-IN-17 can be used in the development of antibacterial drugs, especially for the study of drug-resistant strains .
    DNA Gyrase-IN-17
  • HY-19128
    CI-990

    PD-131112

    		 Bacterial DNA/RNA Synthesis Infection
    CI-990 (PD-131112) is an orally active and highly selective bacterial DNA gyrase inhibitor. CI-990 is promising for research of Enterococcal infections (e.g., endocarditis, sepsis) .
    CI-990
  • HY-183275
    Antibacterial agent 340

    		DNA/RNA Synthesis Bacterial Reactive Oxygen Species (ROS) Infection
    Antibacterial agent 340 is a DNA gyrase inhibitor. Antibacterial agent 340 exhibits broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Antibacterial agent 340 disrupts bacterial cell membrane integrity, induces reactive oxygen species (ROS) accumulation, and inhibits and eradicates bacterial biofilms. Antibacterial agent 340 can be used for the research of bacterial infections .
    Antibacterial agent 340
  • HY-182074
    DNA Gyrase-IN-18

    		Bacterial Topoisomerase Infection
    DNA Gyrase-IN-18 (Compound 6B) is a DNA Gyrase inhibitor and Antibacterial agent. DNA Gyrase-IN-18 significantly inhibits the supercoiling activity of DNA Gyrase. DNA Gyrase-IN-18 inhibits biofilm formation by *Staphylococcus aureus*. DNA Gyrase-IN-18 exhibits excellent antibacterial activity, with a MIC of 0.125 μg/mL against Staphylococcus aureus and a MIC of 0.5 μg/mL against Mycobacterium tuberculosis .
    DNA Gyrase-IN-18
  • HY-181820
    Topoisomerase IV-IN-3

    		Topoisomerase DNA Glycosylase Bacterial Infection
    Topoisomerase IV-IN-3 is a Staphylococcus aureus Topoisomerase IV inhibitor, DNA gyrase inhibitor and antibacterial agent. Topoisomerase IV-IN-3 has IC50 values of 1.32 μM and 0.48 μM against topoisomerase IV, and 0.88 μM and 0.54 μM against DNA gyrase. Topoisomerase IV-IN-3 inhibits decatenation, ATPase, and supercoiling activities of its target enzymes. Topoisomerase IV-IN-3 exerts antibacterial activity against Gram-positive and Gram-negative bacterial strains. Topoisomerase IV-IN-3 exhibits low cytotoxicity toward human fibroblast cells. Topoisomerase IV-IN-3 can be used for the research of bacterial infections .
    Topoisomerase IV-IN-3
  • HY-181107
    DNA Gyrase/ribosomes-IN-1

    		Bacterial DNA/RNA Synthesis Cytochrome P450 Infection
    DNA Gyrase/ribosomes-IN-1 is a bacterial ribosome and DNA gyrase inhibitor, with IC50 values of 1.11 μM and 3.31 μM, respectively. DNA Gyrase/ribosomes-IN-1 also inhibits CYP3A4, with an IC50 of 18.5 μM, and exhibits stability in mouse plasma and liver microsomes. DNA Gyrase/ribosomes-IN-1 inhibits bacterial protein synthesis by interacting with ribosomal RNA and associated sites. DNA Gyrase/ribosomes-IN-1 suppresses bacterial DNA replication by interacting with the gyrase complex. DNA Gyrase/ribosomes-IN-1 restores activity against macrolide-resistant, erm-mediated Gram-positive pathogens and enhances activity against Gram-negative bacteria such as Haemophilus influenzae and Moraxella catarrhalis. DNA Gyrase/ribosomes-IN-1 can be used in research on community-acquired bacterial pneumonia .
    DNA Gyrase/ribosomes-IN-1

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