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Cat. No.: HY-149294

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DNA Gyrase-IN-8

DNA Gyrase-IN-8 is a potent DNA gyrase inhibitor with an IC₅₀ value of 8.45 µM. DNA Gyrase-IN-8 shows antimicrobial activity.

For research use only. We do not sell to patients.

CAS No.: 2925308-76-3
Formula: C₁₉H₁₄BrN₅O
Molecular Weight:408.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

DNA Gyrase-IN-8 Chemical Structure

CAS No.: 2925308-76-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

DNA Gyrase-IN-8 is a potent DNA gyrase inhibitor with an IC₅₀ value of 8.45 µM. DNA Gyrase-IN-8 shows antimicrobial activity^[1].

IC₅₀ & Target

IC₅₀: 8.45 µM (DNA gyrase)^[1]

All DNA/RNA Synthesis Isoforms :

In Vitro

DNA Gyrase-IN-8 (compound 10) shows antimicrobial activity with MIC values of 191.36, 191.36 µM for S. aureus (ATCC 6538-P), C. albicans (ATTC 10231), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2925308-76-3
Molecular Weight 408.25
Formula C₁₉H₁₄BrN₅O
SMILES

N=C1CC(N)=NN1C(C2=C(C=CC=C3)C3=NC(C4=CC=C(Br)C=C4)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abd El-Lateef HM, et al. Design and Synthesis of 2-(4-Bromophenyl)Quinoline-4-Carbohydrazide Derivatives via Molecular Hybridization as Novel Microbial DNA-Gyrase Inhibitors. ACS Omega. 2023 May 11;8(20):17948-17965. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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DNA Gyrase-IN-8

All DNA/RNA Synthesis Isoforms