Topoisomerase IV-IN-3
Topoisomerase IV-IN-3 is a Staphylococcus aureus Topoisomerase IV inhibitor, DNA gyrase inhibitor and antibacterial agent. Topoisomerase IV-IN-3 has IC50 values of 1.32 μM and 0.48 μM against topoisomerase IV, and 0.88 μM and 0.54 μM against DNA gyrase. Topoisomerase IV-IN-3 inhibits decatenation, ATPase, and supercoiling activities of its target enzymes. Topoisomerase IV-IN-3 exerts antibacterial activity against Gram-positive and Gram-negative bacterial strains. Topoisomerase IV-IN-3 exhibits low cytotoxicity toward human fibroblast cells. Topoisomerase IV-IN-3 can be used for the research of bacterial infections.
For research use only. We do not sell to patients.
- Formula: C34H42N4O18S
- Molecular Weight:826.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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TOPO IV 1.32 μM (IC50) |
TOPO IV 0.48 μM (IC50) |
DNA Gyrase 0.88 μM (IC50) |
DNA Gyrase 0.54 μM (IC50) |
Topoisomerase IV-IN-3 (compound 6b) (0.78-200 μg/mL) potently inhibits Staphylococcus aureus growth with an MIC of 0.78 μg/mL, and shows variable activity against other tested Gram-positive bacterial strains[1].
Topoisomerase IV-IN-3 (6.25-400 μg/mL) potently inhibits Klebsiella pneumoniae growth with an MIC of 6.25 μg/mL, and shows variable activity against other tested Gram-negative bacterial strains[1].
Topoisomerase IV-IN-3 (0.48-1.32 μM) potently inhibits Staphylococcus aureus topoisomerase IV ATPase activity with an IC50 of 0.48 μM, and shows inhibitory activity against other tested Staphylococcus aureus DNA gyrase and topoisomerase IV functions[1].
Topoisomerase IV-IN-3 shows low cytotoxicity against human WI-38 fibroblast cells with an IC50 of 85.56 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 826.78
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Formula C34H42N4O18S
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SMILES
CC(O[C@H]([C@H]([C@@H](O[C@@H]1COC(C)=O)NC(N/N=C/C2=CC=C(C=C2)N=O)=S)OC(C)=O)[C@@H]1O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COC(C)=O)OC(C)=O)OC(C)=O)OC(C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topoisomerase IV-IN-3 Related Classifications
HY-181820 Related Classifications
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- Topoisomerase IV-IN-3
- Topoisomerase
- DNA Glycosylase
- Bacterial
- Staphylococcus aureus DNA gyrase
- Klebsiella pneumoniae
- Staphylococcus aureus
- human WI-38 fibroblast cells
- ATPase
- decatenation
- human fibroblast cells
- Gram-negative bacterial strains
- Staphylococcus aureus topoisomerase IV
- Gram-positive bacterial strains
- Inhibitor
- inhibitor
- inhibit