Evybactin
Evybactin is a DNA gyrase inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity.
For research use only. We do not sell to patients.
- Formula: C64H89N21O21
- Molecular Weight:1488.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 1 μM (DNA cleavage)[1]
Evybactin (0-1000 µg/mL; 24 h) inhibits Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL[1]. Evybactin (100 µM; 30 min) induces DNA cleavage with an IC50 value of 1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, FaDu and HEK293 cell lines
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Concentration:0-1000 µg/mL
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Incubation Time:24 hours
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Result:Showed no toxicity against HepG2, FaDu and HEK293 human cells with IC50s ＞128 µg/mL.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with E. coli infection[1]
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Dosage:25 and 100 mg/kg
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Administration:Intraperitoneal injection; 25 and 100 mg/kg once
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Result:Showed significant efficacy with a single dose of 25 mg/kg, and protected mice from infection with a single dose of 100 mg/kg, whereas 83% of untreated control animals died in 24 hours.
Chemical Information
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Molecular Weight 1488.52
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Formula C64H89N21O21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Evybactin Related Classifications
HY-P3473 Related Classifications
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