1. Anti-infection
  2. Bacterial
  3. Evybactin

Evybactin 

Cat. No.: HY-P3473
Handling Instructions

Evybactin is a DNA gyrase inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Evybactin Chemical Structure

Evybactin Chemical Structure

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Description

Evybactin is a DNA gyrase inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity[1].

IC50 & Target

IC50: 1 μM (DNA cleavage)[1]

In Vitro

Evybactin (0-1000 µg/mL; 24 h) inhibits Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL[1].
Evybactin (100 µM; 30 min) induces DNA cleavage with an IC50 value of 1 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HepG2, FaDu and HEK293 cell lines
Concentration: 0-1000 µg/mL
Incubation Time: 24 hours
Result: Showed no toxicity against HepG2, FaDu and HEK293 human cells with IC50s >128 µg/mL.
In Vivo

Evybactin (25-100 mg/kg; i.p. once) effectively inhibits E. coli infection in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with E. coli infection[1]
Dosage: 25 and 100 mg/kg
Administration: Intraperitoneal injection; 25 and 100 mg/kg once
Result: Showed significant efficacy with a single dose of 25 mg/kg, and protected mice from infection with a single dose of 100 mg/kg, whereas 83% of untreated control animals died in 24 hours.
Molecular Weight

1488.52

Formula

C64H89N21O21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Evybactin
Cat. No.:
HY-P3473
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