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Cat. No.: HY-182074

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DNA Gyrase-IN-18

DNA Gyrase-IN-18 (Compound 6B) is a DNA Gyrase inhibitor and Antibacterial agent. DNA Gyrase-IN-18 significantly inhibits the supercoiling activity of DNA Gyrase. DNA Gyrase-IN-18 inhibits biofilm formation by *Staphylococcus aureus*. DNA Gyrase-IN-18 exhibits excellent antibacterial activity, with a MIC of 0.125 μg/mL against Staphylococcus aureus and a MIC of 0.5 μg/mL against Mycobacterium tuberculosis.

For research use only. We do not sell to patients.

Formula: C₂₀H₁₆BrN₅O
Molecular Weight:422.28

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Please store the product under the recommended conditions in the Certificate of Analysis.

DNA Gyrase-IN-18 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All Topoisomerase Isoforms :

In Vitro

DNA Gyrase-IN-18 (0.03-64 μg/mL; 18-24 h) potently inhibits growth of Staphylococcus aureus (ATCC 29213) with a MIC of 0.125 μg/mL after 18-24 h incubation at 37 °C^[1].
DNA Gyrase-IN-18 (0.03-64 μg/mL; 7 days) potently inhibits growth of Mycobacterium tuberculosis (MC 26230) with a MIC of 0.5 μg/mL after 7 days incubation at 37 °C^[1].
DNA Gyrase-IN-18 (0.19-200 μg/mL; 24 h) shows low cytotoxicity against HepG2 cells with a CC₅₀ of 103.6 μg/mL, yielding a high selectivity index of 828.8 for Staphylococcus aureus (ATCC 29213)^[1].
DNA Gyrase-IN-18 (0.25-128 μg/mL; 48 h) inhibits biofilm formation by Staphylococcus aureus (ATCC 29213) with an MBIC₅₀ of 0.309 μg/mL after 48 h static incubation at 37 °C^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 422.28
Formula C₂₀H₁₆BrN₅O
SMILES

O=C(N/N=C\C1=CNC2=C1C=CC=C2)CN3C=CC(C4=CC=C(C=C4)Br)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bellapukonda SM, et al. Exploration of 1,3-di substituted pyrazole conjugates as DNA gyrase inhibitors to combat Staphylococcus aureus and Mycobacterium tuberculosis. Bioorg Chem. Published online March 4, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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DNA Gyrase-IN-18

All Topoisomerase Isoforms