2. Cell Cycle/DNA Damage Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. DNA/RNA Synthesis Bacterial Reactive Oxygen Species (ROS)
  4. Antibacterial agent 340

Antibacterial agent 340 is a DNA gyrase inhibitor. Antibacterial agent 340 exhibits broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Antibacterial agent 340 disrupts bacterial cell membrane integrity, induces reactive oxygen species (ROS) accumulation, and inhibits and eradicates bacterial biofilms. Antibacterial agent 340 can be used for the research of bacterial infections.

For research use only. We do not sell to patients.

Antibacterial agent 340

Antibacterial agent 340 Chemical Structure

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Antibacterial agent 340 Related Antibodies

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Description

Antibacterial agent 340 is a DNA gyrase inhibitor. Antibacterial agent 340 exhibits broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Antibacterial agent 340 disrupts bacterial cell membrane integrity, induces reactive oxygen species (ROS) accumulation, and inhibits and eradicates bacterial biofilms. Antibacterial agent 340 can be used for the research of bacterial infections[1].

In Vitro

Antibacterial agent 340 (Compound IN 6a) (24 h) potently inhibits growth of Gram-positive bacterial strains with MIC values of 0.03 μg/mL (MRSA) and 0.25 μg/mL (all other strains)[1].
Antibacterial agent 340 (24 h) potently inhibits growth of Gram-negative bacterial strains with MIC values of 0.06 μg/mL (Klebsiella pneumoniae) and 0.25 μg/mL (all other non-P. aeruginosa strains), while showing reduced activity against P. aeruginosa strains with MIC values of 32 to 128 μg/mL[1].
Antibacterial agent 340 exhibits low cytotoxicity against HUVEC cells[1].
Antibacterial agent 340 (2 h) exhibits low hemolytic activity against human erythrocytes, with hemolysis rates below 5% even at a concentration of 256× MIC after 2 h of incubation[1].
Antibacterial agent 340 has a low propensity to induce resistance in MRSA and Klebsiella pneumoniae, with stable MIC values maintained over 24-30 generations[1].
Antibacterial agent 340 exhibits sustained inhibitory activity and low cross-resistance against Norfloxacin (HY-B0132)-, Ciprofloxacin (HY-B0356)-, Cefdinir (HY-B0136)-, and multidrug-resistant MRSA, as well as Norfloxacin-, Ciprofloxacin-, Cefixime-, and multidrug-resistant Klebsiella pneumoniae, with low MIC values maintained for at least 20 generations[1].
Antibacterial agent 340 (24 小时) inhibits biofilm formation in MRSA and Klebsiella pneumoniae in a concentration-dependent manner[1].
Antibacterial agent 340 eradicates pre-formed biofilms in MRSA and Klebsiella pneumoniae in a concentration-dependent manner[1].
Antibacterial agent 340 (60 min) induces membrane depolarization in MRSA and Klebsiella pneumoniae[1].
Antibacterial agent 340 (180 min) increases outer membrane permeability in Klebsiella pneumoniae, but does not affect the outer membrane permeability of Pseudomonas aeruginosa ATCC 9027[1].
Antibacterial agent 340 (6 h) increases inner membrane permeability in MRSA and Klebsiella pneumoniae in a concentration-dependent manner[1].
Antibacterial agent 340 (0.133 mg/kg) provides superior in vivo protection against MRSA infection in Galleria mellonella larvae, resulting in an 80% survival rate on day four post-treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 340 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Tmax Cmax AUC0-t AUC0-∞ Vz CL MRT0-t MRT0-∞ F C0
Mice[1] 10 mg/kg i.v. 0.82 h 0.033 h 341 ng/mL 82.3 ng·h/mL 84.1 ng·h/mL 6961 mL/kg 11907 mL/h/kg 0.49 h 0.59 h / 680 ng/mL
Mice[1] 1 mg/kg p.o. 1.23 h 0.25 h 19.2 ng/mL 28.4 ng·h/mL 29.1 ng·h/mL 626272 mL/kg 348155 mL/h/kg 1.59 h 1.83 h 3.46 % /
In Vivo

Antibacterial agent 340 (Compound IN 6a) (1-10 mg/kg; i.v. or p.o.; single dose) exhibits a poor oral bioavailability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (female; 7-week-old; 20-25 g)[1]
Dosage: 1 mg/kg (p.o.); 10 mg/kg (i.v.)
Administration: i.v. or p.o.; single dose
Result: Exhibited T1/2 of 0.82 h, Tmax of 0.033 h, Cmax of 341 ng/mL, AUC0-t of 82.3 ng·h/mL, AUC0-∞ of 84.1 ng·h/mL, VZ of 6961 mL/kg, CL of 11907 mL/h/kg, MRT0-t of 0.49 h and MRT0-∞ of 0.59 h at 10 mg/kg (i.v.).
Exhibited T1/2 of 1.23 h, Tmax of 0.25 h, Cmax of 19.2 ng/mL, AUC0-t of 28.4 ng·h/mL, AUC0-∞ of 29.1 ng·h/mL, VZ of 626272 mL/kg, CL of 348155 mL/h/kg, MRT0-t of 1.59 h and MRT0-∞ of 1.83 h at 1 mg/kg (p.o.).
Exhibited a poor oral bioavailability of 3.46% (p.o.).
Molecular Weight

397.34

Formula

C19H15N3O7
SMILES

CC1=CC(OC2=C1C=CC(OCC(N/N=C/C=C/C3=CC=C(O3)[N+]([O-])=O)=O)=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Antibacterial agent 340 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 340Antibacterial agent340Antibacterial agent-340DNA/RNA SynthesisBacterialReactive Oxygen Species (ROS)HUVEC cellsreactive oxygen speciesMRSAGalleria mellonella larvaeDNA gyrasebacterial biofilmsKlebsiella pneumoniaeGram-negative bacteriabacterial cell membraneGram-positive bacteriaInhibitorinhibitorinhibit

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