1. Anti-infection
  2. Bacterial
  3. Norfloxacin

Norfloxacin (Synonyms: MK-0366)

Cat. No.: HY-B0132 Purity: 99.84%
Handling Instructions

Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

For research use only. We do not sell to patients.

Norfloxacin Chemical Structure

Norfloxacin Chemical Structure

CAS No. : 70458-96-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 g USD 72 In-stock
Estimated Time of Arrival: December 31
10 g USD 120 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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Description

Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

IC50 & Target

DNA gyrase; Antibacterial[1][2].

In Vitro

Norfloxacin (MK-0366) is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance.

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.6 mg/mL (20.67 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1316 mL 15.6578 mL 31.3156 mL
5 mM 0.6263 mL 3.1316 mL 6.2631 mL
10 mM 0.3132 mL 1.5658 mL 3.1316 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

319.33

Formula

C₁₆H₁₈FN₃O₃

CAS No.

70458-96-7

SMILES

O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.84%

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Product Name:
Norfloxacin
Cat. No.:
HY-B0132
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Norfloxacin

Cat. No.: HY-B0132