1. Anti-infection
  2. Bacterial
  3. Cefdinir

Cefdinir (Synonyms: FK-482; CI-983)

Cat. No.: HY-B0136 Purity: 99.56%
Handling Instructions

Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic, which is proved to be effective for common bacterial infections of the ear, sinus, throat, and skin.

For research use only. We do not sell to patients.

Cefdinir Chemical Structure

Cefdinir Chemical Structure

CAS No. : 91832-40-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
1 g USD 108 In-stock
Estimated Time of Arrival: December 31
5 g USD 354 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Description

Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic, which is proved to be effective for common bacterial infections of the ear, sinus, throat, and skin.

IC50 & Target

Antibacterial[1].

In Vitro

Cefdinir (FK-482) is a third generation oral cephalosporin antibiotic. Cefdinir (Omnicef) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for common bacterial infections of the ear, sinus, throat, and skin. It can be used to treat infections caused by several Gram-negative and Gram-positive bacteria. It is available in US as Omnicef by Abbott Laboratories and in India as Cednir by Abbott, Kefnir by Glenmark and Cefdiel by Ranbaxy. As of 2008, cefdinir was the highest-selling cephalosporin antibiotic in the United States, with more than US$585 million in retail sales of its generic versions alone[1]. Cefdinir (FK-482), a new oral 2-amino-5-thiazolyl cephalosporin, inhibited the luminol-amplified chemiluminescence (LACL) response of human neutrophils stimulated by PMA but not opsonized zymosan, in a concentration-dependent but not time-dependent manner. The LACL response to opsonized zymosan in cytochalasin B-treated neutrophils was, however, inhibited by cefdinir. Furthermore, cefdinir inhibited LACL generation in cell-free systems consisting of H2O2, NaI, and either horseradish peroxidase or a myeloperoxidase-containing neutrophil extract. Orthodianisidine oxidation in these two acellular systems was inhibited by cefdinir[2].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (84.29 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5290 mL 12.6451 mL 25.2902 mL
5 mM 0.5058 mL 2.5290 mL 5.0580 mL
10 mM 0.2529 mL 1.2645 mL 2.5290 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.32 mM); Clear solution

References
Molecular Weight

395.41

Formula

C₁₄H₁₃N₅O₅S₂

CAS No.

91832-40-5

SMILES

O=C(C(N12)=C(C=C)CS[[email protected]]2([H])[[email protected]](NC(/C(C3=CSC(N)=N3)=N\O)=O)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere

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Cefdinir
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HY-B0136
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Cefdinir

Cat. No.: HY-B0136