1. Anti-infection
  2. Antibiotic
    Bacterial
  3. Cephalexin

Cephalexin (Synonyms: Cefalexin; Cephacillin)

Cat. No.: HY-B0200 Purity: 99.69%
Handling Instructions

Cephalexin (Cefalexin) is a potent, orally active semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al.

For research use only. We do not sell to patients.

Cephalexin Chemical Structure

Cephalexin Chemical Structure

CAS No. : 15686-71-2

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Customer Review

Based on 6 publication(s) in Google Scholar

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Description

Cephalexin (Cefalexin) is a potent, orally active semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al[1][2].

In Vitro

Cephalexin (10 μg/mL) disrupts polymer peptidoglycan (PG) biogenesis by inactivating enzymes called penicillin-binding proteins (PBPs)[1].
Cephalexin inhibits a broad spectrum of grampositive and gram-negative organisms with MIC values of 2, 2, 2, 2, 4, 4.4 and 5.7 μg/mL for Bacillus anthracis, Edwardsiella taFda, Vibrio cholera, Pasteurella multocida, Edwardsiella tarda, Alcaligenes sp and Proteus rettgeri, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cephalexin (0-50 mg/kg; p.o.; for 3.5 hours) has antibacterial activity in male Swiss-Webster mice with infected bacterial[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss-Webster mice with infected bacterial[2]
Dosage: 0-50 mg/kg
Administration: Oral administration; for 3.5 hours
Result: Had antibacterial activity against Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus and several gram-negative species mice.
Clinical Trial
Molecular Weight

347.39

Formula

C16H17N3O4S

CAS No.
SMILES

O=C(C(N12)=C(C)CS[[email protected]]2([H])[[email protected]](NC([[email protected]](N)C3=CC=CC=C3)=O)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (28.79 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8786 mL 14.3930 mL 28.7861 mL
5 mM 0.5757 mL 2.8786 mL 5.7572 mL
10 mM 0.2879 mL 1.4393 mL 2.8786 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.69%

References
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