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  3. Antibiotic
    Bacterial
  4. Cephalexin monohydrate

Cephalexin monohydrate  (Synonyms: Cefalexin hydrate; Cephacillin hydrate)

Cat. No.: HY-B0200B Purity: 98.91%
COA Handling Instructions

Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al.

For research use only. We do not sell to patients.

Cephalexin monohydrate Chemical Structure

Cephalexin monohydrate Chemical Structure

CAS No. : 23325-78-2

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 55 In-stock
Solid
500 mg USD 50 In-stock
1 g USD 60 In-stock
5 g USD 96 In-stock
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50 g   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Cephalexin monohydrate:

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Description

Cephalexin (Cefalexin) monohydrate is a potent, orally active new semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin (Cefalexin) monohydrate has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin (Cefalexin) monohydrate targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin (Cefalexin) monohydrate is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al[1][2].

IC50 & Target

β-lactam

 

In Vitro

Cephalexin (Cefalexin) monohydrate (10 μg/mL) disrupts polymer peptidoglycan (PG) biogenesis by inactivating enzymes called penicillin-binding proteins (PBPs)[1].
Cephalexin (Cefalexin) monohydrate inhibits a broad spectrum of grampositive and gram-negative organisms with MIC values of 2, 2, 2, 2, 4, 4.4 and 5.7 μg/mL for Bacillus anthracis, Edwardsiella taFda, Vibrio cholera, Pasteurella multocida, Edwardsiella tarda, Alcaligenes sp and Proteus rettgeri, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Cephalexin (Cefalexin) monohydrate (0-50 mg/kg; p.o.; for 3.5 hours) has antibacterial activity in male Swiss-Webster mice with infected bacterial[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss-Webster mice with infected bacterial[2]
Dosage: 0-50 mg/kg
Administration: Oral administration; for 3.5 hours
Result: Had antibacterial activity against Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus and several gram-negative species mice.
Clinical Trial
Molecular Weight

365.40

Appearance

Solid

Formula

C16H19N3O5S
CAS No.
SMILES

O=C(C(N12)=C(C)CS[[email protected]]2([H])[[email protected]](NC([[email protected]](N)C3=CC=CC=C3)=O)C1=O)O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.67 mg/mL (18.25 mM; Need ultrasonic)

H2O : 2 mg/mL (5.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7367 mL 13.6836 mL 27.3673 mL
5 mM 0.5473 mL 2.7367 mL 5.4735 mL
10 mM 0.2737 mL 1.3684 mL 2.7367 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 8.33 mg/mL (22.80 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.67 mg/mL (1.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.67 mg/mL (1.83 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.67 mg/mL (1.83 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.91%

COA (258 KB) HNMR (269 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Cephalexin23325-78-2CefalexinCephacillinAntibioticBacterialgram-positive bacteriagram-negative bacteriapenicillin-binding proteinscell wall assemblyInhibitorinhibitorinhibit

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