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  3. Antibiotic
  4. Cephalexin sodium

Cephalexin sodium is an orally active cephalosporin Antibiotic. Cephalexin sodium disrupts bacterial cell wall synthesis and inhibits the growth of susceptible Gram-positive bacteria and some Gram-negative bacteria. Cephalexin sodium induces acute renal failure when overdosed in laboratory animals. Cephalexin sodium can be used in studies related to bacterial infections.

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Cephalexin sodium

Cephalexin sodium Chemical Structure

CAS No. : 38932-40-0

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Cephalexin sodium Related Antibodies

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Description

Cephalexin sodium is an orally active cephalosporin Antibiotic. Cephalexin sodium disrupts bacterial cell wall synthesis and inhibits the growth of susceptible Gram-positive bacteria and some Gram-negative bacteria. Cephalexin sodium induces acute renal failure when overdosed in laboratory animals. Cephalexin sodium can be used in studies related to bacterial infections[1][2][3][4].

In Vitro

Cephalexin (30 μg per disc) sodium exhibits in vitro activity against most indole-negative Proteus sp., Escherichia coli, Salmonella sp., Shigella sp., and Paracolobactrum sp. strains, but no activity against indole-positive Proteus sp., Pseudomonas sp., or Alcaligenes sp., and partial activity against Klebsiella-Aerobacter spp. when tested via 30-μg disc assay[3].
Cephalexin (15-30 μg per disc) sodium potently inhibits most gram-positive bacteria and Neisseria sp. in vitro, with MIC values ranging from 0.16 μg/mL (Neisseria meningitidis strain Suederlin) to 200 μg/mL (Streptococcus sp. group D strain 9960), and disc-plate zones of inhibition correlating with tube dilution sensitivity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cephalexin sodium Related Antibodies
In Vivo

Cephalexin (1.15-58.2 mg/kg; p.o.; two doses at 1 and 5 hours post-infection) demonstrates potent in vivo efficacy against experimental gram-positive bacterial infections in mice, with ED50 values ranging from 1.15 mg/kg to 58.2 mg/kg across tested strains[3].
Cephalexin (<10->166 mg/kg; p.o.; two doses at 1 and 5 hours post-infection) exhibits in vivo efficacy against a range of experimental gram-negative bacterial infections in mice, with ED50 values ranging from <10 mg/kg to >166 mg/kg depending on the bacterial strain[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: McAllister strain (11 to 13 g)[3]
Dosage: Not specified
Administration: p.o.; two doses at 1 and 5 hours post-infection
Result: Achieved an oral ED50 of 1.15 mg/kg against penicillin-sensitive S. aureus strain 3055.
Achieved an oral ED50 of 3.7 mg/kg against penicillin-resistant S. aureus strain 3074.
Achieved an oral ED50 of 1.8 mg/kg against Streptococcus pyogenes strain C203.
Achieved an oral ED50 of 58.2 mg/kg against Diplococcus pneumoniae Type I.
Animal Model: McAllister strain (11 to 13 g)[3]
Dosage: Not specified
Administration: p.o.; two doses at 1 and 5 hours post-infection
Result: Achieved an oral ED50 of 22.1 mg/kg against indole-negative Proteus sp. strain PR-4.
Achieved oral ED50 values >166 mg/kg against indole-positive Proteus sp. strains PR-9 and PR-15.
Achieved an oral ED50 of 18.9 mg/kg against Salmonella typhosa strain SA-12.
Achieved an oral ED50 of <10 mg/kg against Shigella flexneri 2b strain SH-3.
Achieved an oral ED50 of 5.2 mg/kg against Klebsiella-Aerobacter spp. strain KA-14.
Achieved an oral ED50 of 166 mg/kg against Klebsiella-Aerobacter spp. strain KA-17.
Achieved an oral ED50 of 11.7 mg/kg against Escherichia coli strain EC-14.
Achieved an oral ED50 >166 mg/kg against Escherichia coli strain EC-17.
Achieved an oral ED50 <10 mg/kg against Escherichia coli strain EC-38.
Molecular Weight

369.37

Formula

C16H16N3NaO4S
CAS No.
SMILES

O=C1N2[C@@](SCC(C)=C2C(O[Na])=O)([H])[C@@H]1NC([C@@H](C3=CC=CC=C3)N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cephalexin sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cephalexin38932-40-0AntibioticShigella sp.bacterial cell wall synthesisProteus sp.cephalosporin β-lactam antibioticGram-positive bacteriaEscherichia coliStaphylococcus aureusGram-negative bacteriaVibrio fischeriSalmonella sp.Inhibitorinhibitorinhibit

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