1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cefuroxime

Cefuroxime 

Cat. No.: HY-B1256A
Handling Instructions

Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria.

For research use only. We do not sell to patients.

Cefuroxime Chemical Structure

Cefuroxime Chemical Structure

CAS No. : 55268-75-2

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Description

Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria[1].

In Vitro

Cefuroxime is highly active against S. aureus (MIC=0.25 μg/ml), regardless of whether the strains produces a penicillinase. It is against Staphylococcus aureus methicillin susceptible; S. aureus, methicillin resistant, Streptococcus pyogenes, S. pneumoniae, S. viridans, S. faecalis, and Clostridium spp with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively[1].
Cefuroxime (10-100 μg/ml; 2-6 hours) rapidly bactericidal, its action is comparatively slow against the strains of S. aureus, but, even so, over 99% of the initial inoculum is killed by 6 h. The gram-negative organisms are killed rapidly, and in most cases over 99% of the very large inocula are killed within 2 h; the β-lactamase-producing strains are killed as quickly as non-enzyme-producing strains[1].

In Vivo

Rabbits (weighing 2.0 to 2.5 kg) are challenged intravenously with S. aureus strain 630 (a penicillinase-producing strain), the median effective dose of Cefuroxime is 3 mg/kg as a result of the protection test[2].

Molecular Weight

424.39

Formula

C₁₆H₁₆N₄O₈S

CAS No.

55268-75-2

SMILES

O=C(C(N12)=C(COC(N)=O)CS[[email protected]]2([H])[[email protected]](NC(/C(C3=CC=CO3)=N\OC)=O)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CefuroximeBacterialAntibioticStaphylococcus aureusS. aureusEscherichia coliStreptococcus pyogenesS. faecalisβ-lactamaseInhibitorinhibitorinhibit

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