1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cefuroxime sodium

Cefuroxime sodium 

Cat. No.: HY-B1256 Purity: 99.33%
Handling Instructions

Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria.

For research use only. We do not sell to patients.

Cefuroxime sodium Chemical Structure

Cefuroxime sodium Chemical Structure

CAS No. : 56238-63-2

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
500 mg USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 96 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria[1].

In Vitro

Cefuroxime sodium is highly active against S. aureus (MIC=0.25 μg/ml), regardless of whether the strains produces a penicillinase. It is against Staphylococcus aureus methicillin susceptible; S. aureus, methicillin resistant, Streptococcus pyogenes, S. pneumoniae, S. viridans, S. faecalis, and Clostridium spp with MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively[1].
Cefuroxime sodium (10-100 μg/ml; 2-6 hours) rapidly bactericidal, its action is comparatively slow against the strains of S. aureus, but, even so, over 99% of the initial inoculum is killed by 6 h. The gram-negative organisms are killed rapidly, and in most cases over 99% of the very large inocula are killed within 2 h; the β-lactamase-producing strains are killed as quickly as non-enzyme-producing strains[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rabbits (weighing 2.0 to 2.5 kg) are challenged intravenously with S. aureus strain 630 (a penicillinase-producing strain), the median effective dose of Cefuroxime sodium is 3 mg/kg as a result of the protection test[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

446.37

Formula

C₁₆H₁₅N₄NaO₈S

CAS No.

56238-63-2

SMILES

O=C(C(N12)=C(COC(N)=O)CS[[email protected]]2([H])[C[email protected]](NC(/C(C3=CC=CO3)=N\OC)=O)C1=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (224.03 mM)

H2O : 50 mg/mL (112.01 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2403 mL 11.2015 mL 22.4029 mL
5 mM 0.4481 mL 2.2403 mL 4.4806 mL
10 mM 0.2240 mL 1.1201 mL 2.2403 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

  • 3.

    Add each solvent one by one:  PBS

    Solubility: 55 mg/mL (123.22 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.33%

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Keywords:

CefuroximeBacterialAntibioticStaphylococcus aureusS. aureusEscherichia coliStreptococcus pyogenesS. faecalisβ-lactamaseInhibitorinhibitorinhibit

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Cefuroxime sodium
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HY-B1256
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