1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cefditoren (Pivoxil)

Cefditoren (Pivoxil) (Synonyms: Cefditoren pivoxyl; Cefditoren pivaloyloxymethyl ester; ME 1207)

Cat. No.: HY-17452A Purity: 99.31%
Handling Instructions

Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.

For research use only. We do not sell to patients.

Cefditoren (Pivoxil) Chemical Structure

Cefditoren (Pivoxil) Chemical Structure

CAS No. : 117467-28-4

Size Price Stock Quantity
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Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 185 In-stock
Estimated Time of Arrival: December 31
100 mg USD 251 In-stock
Estimated Time of Arrival: December 31
200 mg USD 304 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Description

Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections[1][2].

In Vitro

Cefditoren (Pivoxil) shows good activity against pneumoniae, S. pyogenes, Staphylococcus aureus, H. influenzae and H. parainfluenzae, M. catarrhalis[1].

Organism MIC50 (mg/L) MIC90 (mg/L) susceptible (%)
Gram-positive organisms
Streptococcus pneumoniae
(untyped)a
0.015-0.25 0.12-1
PS ≤0.008-0.03 0.015-0.25 99-100
PI 0.06-0.5 0.25-0.5 94-100
PR 0.25-1 0.5-2 7-100
S. pyogenes ≤0.008-0.03 0.015-0.03 100
Staphylococcus aureus (MS) 0.12-0.5 0.5-1 50-100
Gram-negative organisms
Haemophilus ≤0.008-≤0.03 0.015-0.13
influenzae (untyped)b
β-Lactamase + ≤0.008-0.03 0.015-0.06 100
β-Lactamase - ≤0.008-0.03 0.015-0.06 100
H. parainfluenzaeb ≤0.03 0.06
Moraxella 0.03-0.5 0.25-1 96
catarrhalis (untyped)b

β-Lactamase + ≤0.03-0.25 0.12-0.5 100
β-Lactamase - ≤0.008-0.03 0.015-0.06 100
a Including PS, PI and PR strains.
b Including both β-lactamase-positive and -negative strains.
MIC50/90=mean minimum inhibitory concentrations required to inhibit the growth of 50% or 90% of bacterial strains; MS=susceptible to meticillin; PI=intermediate susceptibility to penicillin; PR=resistant to penicillin; PS=susceptible to penicillin.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetics in mice[1]

Cefditoren (mg/kg) C0 (µg/ml) t1/2 (h) AUClast (µg× h/ml) Tlast (h)
6.25 53.0 0.9 30.4 6
12.5 168.4 1.1 64.1 8
25 232.5 0.9 101.3 8
50 290.6 1.1 124.4 8

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

620.72

Formula

C25H28N6O7S3

CAS No.
SMILES

O=C(C(N12)=C(/C=C\C3=C(C)N=CS3)CS[[email protected]]2([H])[[email protected]](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)OCOC(C(C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (161.10 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6110 mL 8.0552 mL 16.1103 mL
5 mM 0.3222 mL 1.6110 mL 3.2221 mL
10 mM 0.1611 mL 0.8055 mL 1.6110 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.03 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Cefditoren (Pivoxil)
Cat. No.:
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