Cefsulodin sodium hydrate  (Synonyms: SCE-129 sodium hydrate)

Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC₅₀ value of 16 μM^[1][2][3][4].

Cefsulodin sodium (0.5-64 mg/mL; 18 h) is active in minimum inhibitory concentrations (MICs) of 0.5-64 mg/mL, is about 16- to 32-fold more active than Carbenicillin (HY-B0525) against Psuedomonas aeruginosa^[1].
Cefsulodin sodium (8-16 μg/mL; 4.5 h) is not hydrolyzed by the beta-lactamase induced in P. aeruginosa by growth in the presence of benzylpenicillin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefsulodin sodium (1 g/kg/tag; i.p.; 5 d, 9 single doses with intervals of 12 h) shows a increasing excretion of tubule cells in the rat, as a measure of nephrotoxicity, and displays tubule toxic threshold doses of 250 mg/kg (s.c.; 12 d) with nine single doses^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

554.53 (Anhydrous)

C₂₂H₁₉N₄O₈S₂.Na.XH2O

1426397-23-0

[O-]C(C1=C(C[N+]2=CC=C(C(N)=O)C=C2)CS[C@@]([C@@H]3NC([C@@H](C4=CC=CC=C4)S(=O)(O[Na])=O)=O)([H])N1C3=O)=O.[F,Cl,Br,I].O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. King A, et al. In vitro antibacterial activity and susceptibility of cefsulodin, an antipseudomonal cephalosporin, to beta-lactamases. Antimicrob Agents Chemother. 1980 Feb;17(2):165-9.  [Content Brief]

  [2]. Gotoh N, et al. Resistance of Pseudomonas aeruginosa to cefsulodin: modification of penicillin-binding protein 3 and mapping of its chromosomal gene. J Antimicrob Chemother. 1990 Apr;25(4):513-23.  [Content Brief]

  [3]. He R, et al. Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis. ACS Med Chem Lett. 2015 Nov 3;6(12):1231-5.  [Content Brief]

  [4]. Sack K, et al. Renal tolerance of imipenem/cilastatin and other beta-lactam antibiotics in rats. Infection. 1985;13 Suppl 1:S156-60.  [Content Brief]