2. Anti-infection
  3. Beta-lactamase Bacterial
  4. Cefditoren sodium

Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.

For research use only. We do not sell to patients.

Cefditoren sodium Chemical Structure

Cefditoren sodium Chemical Structure

CAS No. : 104146-53-4

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Based on 1 publication(s) in Google Scholar

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Cefditoren sodium Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections[1][2].

In Vitro

Cefditoren (sodium) shows good activity against pneumoniae, S. pyogenes, Staphylococcus aureus, H. influenzae and H. parainfluenzae, M. catarrhalis[1].

Organism MIC50 (mg/L) MIC90 (mg/L) susceptible (%)
Gram-positive organisms
Streptococcus pneumoniae
(untyped)a		 0.015-0.25 0.12-1
PS ≤0.008-0.03 0.015-0.25 99-100
PI 0.06-0.5 0.25-0.5 94-100
PR 0.25-1 0.5-2 7-100
S. pyogenes ≤0.008-0.03 0.015-0.03 100
Staphylococcus aureus (MS) 0.12-0.5 0.5-1 50-100
Gram-negative organisms
Haemophilus ≤0.008-≤0.03 0.015-0.13
influenzae (untyped)b
β-Lactamase + ≤0.008-0.03 0.015-0.06 100
β-Lactamase - ≤0.008-0.03 0.015-0.06 100
H. parainfluenzaeb ≤0.03 0.06
Moraxella 0.03-0.5 0.25-1 96
catarrhalis (untyped)b
β-Lactamase + ≤0.03-0.25 0.12-0.5 100
β-Lactamase - ≤0.008-0.03 0.015-0.06 100
a Including PS, PI and PR strains.
b Including both β-lactamase-positive and -negative strains.
MIC50/90=mean minimum inhibitory concentrations required to inhibit the growth of 50% or 90% of bacterial strains; MS=susceptible to meticillin; PI=intermediate susceptibility to penicillin; PR=resistant to penicillin; PS=susceptible to penicillin.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefditoren sodium Related Antibodies
In Vivo

Pharmacokinetics in mice[1]：

Cefditoren (mg/kg) C0 (µg/ml) t1/2 (h) AUClast (µg× h/ml) Tlast (h)
6.25 53.0 0.9 30.4 6
12.5 168.4 1.1 64.1 8
25 232.5 0.9 101.3 8
50 290.6 1.1 124.4 8

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

528.56

Formula

C19H17N6NaO5S3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=C(/C=C\C2=C(N=CS2)C)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC)=O)([H])N1C3=O)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (189.19 mM; Need ultrasonic)

DMSO : 31.25 mg/mL (59.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8919 mL 9.4597 mL 18.9193 mL
5 mM 0.3784 mL 1.8919 mL 3.7839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.73 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.73 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.8919 mL 9.4597 mL 18.9193 mL 47.2983 mL
5 mM 0.3784 mL 1.8919 mL 3.7839 mL 9.4597 mL
10 mM 0.1892 mL 0.9460 mL 1.8919 mL 4.7298 mL
15 mM 0.1261 mL 0.6306 mL 1.2613 mL 3.1532 mL
20 mM 0.0946 mL 0.4730 mL 0.9460 mL 2.3649 mL
25 mM 0.0757 mL 0.3784 mL 0.7568 mL 1.8919 mL
30 mM 0.0631 mL 0.3153 mL 0.6306 mL 1.5766 mL
40 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1825 mL
50 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.9460 mL
H2O 60 mM 0.0315 mL 0.1577 mL 0.3153 mL 0.7883 mL
80 mM 0.0236 mL 0.1182 mL 0.2365 mL 0.5912 mL
100 mM 0.0189 mL 0.0946 mL 0.1892 mL 0.4730 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cefditoren sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefditoren104146-53-4ME 1206ME1206ME-1206Beta-lactamaseBacterialβ-lactamasebroad-spectrum antibioticthird-generationoral cephalosporinβ lactamasesinfection diseasesInhibitorinhibitorinhibit

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