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  3. Cefcapene pivoxil hydrochloride hydrate

Cefcapene pivoxil hydrochloride hydrate 

Cat. No.: HY-W040022 Purity: 99.36%
Handling Instructions

Cefcapene pivoxil hydrochloride hydrate is a prodrug and an orally active 3rd-generation cephalosporin with broad-spectrum of anti-bacterial activity. Cefcapene pivoxil hydrochloride hydrate is used for the study of palmoplantar pustulosis (PPP) and other infectious diseases.

For research use only. We do not sell to patients.

Cefcapene pivoxil hydrochloride hydrate Chemical Structure

Cefcapene pivoxil hydrochloride hydrate Chemical Structure

CAS No. : 147816-24-8

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25 mg USD 75 In-stock
Estimated Time of Arrival: December 31
50 mg USD 123 In-stock
Estimated Time of Arrival: December 31
100 mg USD 200 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cefcapene pivoxil hydrochloride hydrate:

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Description

Cefcapene pivoxil hydrochloride hydrate is a prodrug and an orally active 3rd-generation cephalosporin with broad-spectrum of anti-bacterial activity[1]. Cefcapene pivoxil hydrochloride hydrate is used for the study of palmoplantar pustulosis (PPP) and other infectious diseases[2].

IC50 & Target

IC50: bacterial[1]

In Vivo

Cefcapene pivoxil hydrochloride hydrate (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, it stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109 CFU)[3]
Dosage: 100 mg/kg
Administration: Oral administration; 100mg/kg; 4 days
Result: Was against H. influenzae colonization in mouse lung.
Molecular Weight

622.11

Formula

C23H32ClN5O9S2

CAS No.
SMILES

[H]Cl.O=C1N([[email protected]@]([H])([[email protected]@H]1NC(/C(C2=CSC(N)=N2)=C\CC)=O)SC3)C(C(OCOC(C(C)(C)C)=O)=O)=C3COC(N)=O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (200.93 mM; Need ultrasonic)

H2O : 1 mg/mL (1.61 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6074 mL 8.0372 mL 16.0743 mL
5 mM 0.3215 mL 1.6074 mL 3.2149 mL
10 mM 0.1607 mL 0.8037 mL 1.6074 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.36%

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Product Name:
Cefcapene pivoxil hydrochloride hydrate
Cat. No.:
HY-W040022
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