Cefcapene pivoxil hydrochloride hydrate
Based on 1 Customer Validation
Cefcapene pivoxil hydrochloride hydrate, the pivalate ester prodrug form of Cefcapene, is an orally active third-generation cephalosporin with a wide spectrum of anti-bacterial activity. Cefcapene pivoxil hydrochloride hydrate has the potential for the palmoplantar pustulosis (PPP) research.
For research use only. We do not sell to patients.
- Purity: 99.41%
- CAS No.: 147816-24-8
- Formula: C23H32ClN5O9S2
- Molecular Weight:622.11
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Storage:
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Antibiotic Isoforms
More
Biological Activity
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β-lactam |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109 CFU)[3]
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Dosage:100 mg/kg
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Administration:Oral administration; 100mg/kg; 4 days
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Result:Was against H. influenzae colonization in mouse lung.
Chemical Information
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CAS No. 147816-24-8
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Appearance Solid
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Molecular Weight 622.11
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Formula C23H32ClN5O9S2
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Color White to light yellow
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SMILES
[H]Cl.O=C1N([C@@]([H])([C@@H]1NC(/C(C2=CSC(N)=N2)=C\CC)=O)SC3)C(C(OCOC(C(C)(C)C)=O)=O)=C3COC(N)=O.O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 125 mg/mL (200.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * The compound is unstable in solutions, freshly prepared is recommended.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Murakami M, et al. Cefcapene Pivoxil Hydrochloride Is a Potentially New Treatment for Palmoplantar Pustulosis with Pustulotic Arthro-Osteitis.Dermatology. 2015;231(4):304-11. [Content Brief]
[2]. Koh Okamoto, et al. Poor penetration of cefcapene into aqueous humor after oral administration of cefcapene pivoxil to patients undergoing cataract surgery. J Infect Chemother. 2020 Feb;26(2):312-315. [Content Brief]
[3]. Sekiya Y, et al. Comparative efficacies of different antibiotic treatments to eradicate nontypeable Haemophilus influenzae infection.BMC Infect Dis. 2008 Feb 7;8:15. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.6074 mL | 8.0372 mL | 16.0743 mL | 40.1858 mL |
| 5 mM | 0.3215 mL | 1.6074 mL | 3.2149 mL | 8.0372 mL | |
| 10 mM | 0.1607 mL | 0.8037 mL | 1.6074 mL | 4.0186 mL | |
| 15 mM | 0.1072 mL | 0.5358 mL | 1.0716 mL | 2.6791 mL | |
| 20 mM | 0.0804 mL | 0.4019 mL | 0.8037 mL | 2.0093 mL | |
| 25 mM | 0.0643 mL | 0.3215 mL | 0.6430 mL | 1.6074 mL | |
| 30 mM | 0.0536 mL | 0.2679 mL | 0.5358 mL | 1.3395 mL | |
| 40 mM | 0.0402 mL | 0.2009 mL | 0.4019 mL | 1.0046 mL | |
| 50 mM | 0.0321 mL | 0.1607 mL | 0.3215 mL | 0.8037 mL | |
| 60 mM | 0.0268 mL | 0.1340 mL | 0.2679 mL | 0.6698 mL | |
| 80 mM | 0.0201 mL | 0.1005 mL | 0.2009 mL | 0.5023 mL | |
| 100 mM | 0.0161 mL | 0.0804 mL | 0.1607 mL | 0.4019 mL |
Cefcapene pivoxil hydrochloride hydrate Related Classifications
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