1. Anti-infection
  2. Bacterial
  3. Cefcapene pivoxil hydrochloride

Cefcapene pivoxil hydrochloride 

Cat. No.: HY-135221
Handling Instructions

Cefcapene pivoxil hydrochloride, an antibiotic, is an orally active and potent 3rd-generation cephalosporin with a wide spectrum of anti-bacterial activity.Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) treatment.

For research use only. We do not sell to patients.

Cefcapene pivoxil hydrochloride Chemical Structure

Cefcapene pivoxil hydrochloride Chemical Structure

CAS No. : 147816-23-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 104 In-stock
Estimated Time of Arrival: December 31
5 mg USD 78 In-stock
Estimated Time of Arrival: December 31
10 mg USD 135 In-stock
Estimated Time of Arrival: December 31
25 mg USD 320 In-stock
Estimated Time of Arrival: December 31
50 mg USD 590 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cefcapene pivoxil hydrochloride, an antibiotic, is an orally active and potent 3rd-generation cephalosporin with a wide spectrum of anti-bacterial activity[1].Cefcapene pivoxil hydrochloride has the potential for the palmoplantar pustulosis (PPP) treatment[2].

IC50 & Target

IC50: bacterial[1]

In Vivo

Cefcapene pivoxil hydrochloride (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration[3].

Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109 CFU)[3]
Dosage: 100 mg/kg
Administration: Oral administration; 100mg/kg; 4 days
Result: Was against H. influenzae colonization in mouse lung.
Molecular Weight

604.10

Formula

C₂₃H₃₀ClN₅O₈S₂

CAS No.

147816-23-7

SMILES

[H]Cl.CC(C)(C)C(OCOC(C1=C(COC(N)=O)CS[[email protected]@]([[email protected]@H]2NC(/C(C3=CSC(N)=N3)=C\CC)=O)([H])N1C2=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (206.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6554 mL 8.2768 mL 16.5536 mL
5 mM 0.3311 mL 1.6554 mL 3.3107 mL
10 mM 0.1655 mL 0.8277 mL 1.6554 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.33 mg/mL (3.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.33 mg/mL (3.86 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.33 mg/mL (3.86 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Cefcapene pivoxilBacterialinfection palmoplantarpustulosisPPP HaemophilusinfluenzaeBLNASInhibitorinhibitorinhibit

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Product name:
Cefcapene pivoxil hydrochloride
Cat. No.:
HY-135221
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