34 Results for "

HA2

" in MedChemExpress (MCE) Product Catalog:
Products (34)

34 Results for "HA2" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P80948B
Synonyms: HA epitope tag antibody; HA1; HA2; hemagglutinin antibody

Host:  

Rabbit

Application:  

WB, ICC/IF, IP

Reactivity:  

Species independent

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Cat. No.: HY-P4108
CAS No.: 923954-79-4
Target:  

Influenza Virus

Research Areas:  

Infection

TAT-HA2 Fusion Peptide is a peptide-based delivery agent that combines the pH-sensitive HA2 fusion peptide from Influenza and the cell-penetrating peptide TAT from HIV. TAT-HA2 Fusion Peptide is a transactivator of transcription and hemaglutanin for endosomal release. TAT-HA2 Fusion Peptide enhances cellular uptake of macromolecules .
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Cat. No.: HY-P10152
CAS No.: 185462-59-3
Research Areas:  

Infection

INF7 is a derivative of the N-terminal domain of the HA2 protein and is sensitive to pH. INF7 disrupts the stability of endosomal membranes through a mechanism independent of membrane fusion. INF7 can be used to enhance the endosome escape of complex or liposome-encapsulated proteins. Co-encapsulation of INF7 and molecular imaging probes in liposomes can enhance intracellular signaling and probe retention [2].
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Cat. No.: HY-P5307
Synonyms: INF7-A5K-TAT
Research Areas:  

Others

Peptide A5K (INF7-A5K-TAT) is an amphiphilic peptide derived from the HA2-TAT fusion scaffold. Peptide A5K can non-covalently bind to CRISPR ribonucleoproteins and efficiently deliver them to cells, such as primary human T cells, B cells, and NK cells. Peptide A5K enables low-toxicity, precise, and multiplex genome editing, holding great application potential in the field of cell therapy .
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Cat. No.: HY-P99750
CAS No.: 1443004-16-7
Synonyms: CT-P23

Target:  

Influenza Virus

Research Areas:  

Infection

Navivumab (CT-P23) is a monoclonal antibody targeting the hemagglutinin (HA) of influenza A virus. Navivumab binds to the HA2 stem fusion domain and the low-variability HA2 region of influenza viruses. Navivumab neutralizes influenza A viruses of subtypes H1, H2, H5, and H9. Navivumab is applicable to research related to influenza and influenza A [2] .
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Cat. No.: HY-139314
CAS No.: 784-90-7
Purity:  99.39%
Target:  

Adenosine Receptor

Research Areas:  

Metabolic Disease

A2B receptor antagonist 2 (compound 18) is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively .
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Cat. No.: HY-N2589
CAS No.: 19416-87-6
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects [2] .
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Cat. No.: HY-P5405
Synonyms: Transducible TAT-HA fusogenic peptide
Target:  

Peptides

Research Areas:  

Others

dTAT-HA2 enhances TAT-Cre escape from macropinosomes. dTAT-HA2 is a transfusible, pH-sensitive, fusogenic peptide .
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Cat. No.: HY-N0092R
CAS No.: 58-63-9
Inosine (Standard) is the analytical standard of Inosine. This product is intended for research and analytical applications. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors [2] . In Vitro:Inosine dose-dependently stimulates cAMP production mediated through the A2AR [2].
Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation [2].
Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes .
In Vivo:Inosine (10-100 mg/kg; i.p.) exhibits antinociceptive effect in mice [2].
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Cat. No.: HY-130178
CAS No.: 1210501-46-4
Target:  

Endogenous Metabolite

Research Areas:  

Infection

CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection. CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319 .
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Cat. No.: HY-P4108C
Research Areas:  

Others

Cys-TAT-HA2 is a conjugate of Cys and TAT-HA2 (HY-P4108). Cys-TAT-HA2 is a transduction complex that can be introduced protein (such as Cardiac troponin C) into the cytoplasm of living cells. Cys-TAT-HA2 can be used for live tracking of exogenous proteins research .
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Cat. No.: HY-P11353
CAS No.: 117138-19-9
Research Areas:  

Infection Cancer

HA2 peptide is a potent pH-responsive fusion peptide derived from hemagglutinin (HA), corresponding to the N-terminal fusion peptide domain consisting of 23 amino acid residues of HIV-1 gp41 envelope glycoprotein. HA2 peptide adopts a random coil structure under physiological pH conditions; in acidic endosomes, protonation of carboxyl groups reduces negative charge, inducing a transition to an α-helical conformation that can fuse with and destabilize the endosomal membrane. After binding to membranes, the N-terminal and middle regions of HA2 peptide mainly adopt a β-strand conformation, while the C-terminal region remains unstructured. HA2 peptide induces lipid mixing and promotes aqueous content leakage from large unilamellar vesicles whose lipid composition matches that of HIV-1 viruses and target T cells. HA2 peptide is anionic and can bind to cationic peptides to achieve siRNA condensation. HA2 peptide can be used in studies related to cancer and human immunodeficiency virus (HIV) infection [2].
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Cat. No.: HY-14365
CAS No.: 1061747-72-5
Purity:  98.11%
Target:  

Adenosine Receptor

Research Areas:  

Neurological Disease

TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively .
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Cat. No.: HY-P11000
Research Areas:  

Others

INF7TAT is an amphipathic peptide containing the influenza HA2 sequence and the TAT peptide (HY-P0281). INF7TAT can associate with other macromolecules through non-covalent associations. INF7TAT can be used for non-toxic delivery of siRNAs .
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Cat. No.: HY-P5307A
Synonyms: INF7-A5K-TAT acetate
Research Areas:  

Others

Peptide A5K (INF7-A5K-TAT) acetate is an amphiphilic peptide derived from the HA2-TAT fusion scaffold. Peptide A5K acetate can non-covalently bind to CRISPR ribonucleoproteins and efficiently deliver them to cells, such as primary human T cells, B cells, and NK cells. Peptide A5K acetate enables low-toxicity, precise, and multiplex genome editing, holding great application potential in the field of cell therapy .
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Cat. No.: HY-103177
CAS No.: 591771-91-4
Target:  

Adenosine Receptor

Research Areas:  

Inflammation/Immunology

PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice [2].
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Cat. No.: HY-163701
CAS No.: 2842150-81-4
Target:  

Adenosine Receptor

Research Areas:  

Cancer

hA2AAR antagonist 1 (compound 4a) is a highly selective hA2AAR antagonist with a Ki of 5 nM. hA2AAR antagonist 1 can be used in the study of immune-oncology .
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Cat. No.: HY-146979
CAS No.: 2548963-55-7
Research Areas:  

Cancer

hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research .
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Cat. No.: HY-RS09943
Research Areas:  

Others

P4HA2 Human Pre-designed siRNA Set A contains three designed siRNAs for P4HA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS25160
Research Areas:  

Others

P4ha2 Rat Pre-designed siRNA Set A contains three designed siRNAs for P4ha2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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