A2AAR antagonist 5

A2AAR antagonist 5 (Compound 3) exhibits potent affinity for hA_2A adenosine receptor with a K_i value of 57 nM, shows no affinity for hA₁ adenosine receptor (K_i > 30,000 nM), has moderate affinity for hA₃ adenosine receptor (K_i = 358 nM), and no activity on hA_2B adenosine receptor (IC₅₀ > 30,000 nM)^[1].
A2AAR antagonist 5 exerts antagonistic activity against hA_2A adenosine receptor in CHO cells expressing hA_2A , with an IC₅₀ value of 1416 nM for inhibiting NECA-stimulated adenylyl cyclase activity^[1].
A2AAR antagonist 5 displays potent free radical scavenging activity, with an EC₅₀ value of 22.21 μM^[1].
A2AAR antagonist 5 (200 nM, administered 15 min before, during Oxygen-Glucose Deprivation (OGD), and 5 min after OGD significantly delays the onset of anoxic depolarization (AD) induced by oxygen-glucose deprivation (OGD) in the CA1 region tested in acute rat hippocampal slices^[1].
A2AAR antagonist 5 (1-10 μM, administered during 30 min OGD and subsequent 24 h recovery) exerts significant neuroprotective effects, reducing OGD-induced neuronal damage in the CA1 subfield tested in rat organotypic hippocampal slices ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.