2. GPCR/G Protein
  3. Adenosine Receptor
  4. A2A/A3 agonist-1

A2A/A3 agonist-1 is a dual A2A/A3 adenosine receptor agonist. A2A/A3 agonist-1 has a Ki value of 2.9 nM and an EC50 of 0.51 nM for hA2AAR. A2A/A3 agonist-1 has a Ki of 0.8 nM and an EC50 < 0.10 nM for hA3AR. A2A/A3 agonist-1 possesses anti-inflammatory activity and can be used for the research of inflammatory diseases.

For research use only. We do not sell to patients.

A2A/A3 agonist-1

A2A/A3 agonist-1 Chemical Structure

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A2A/A3 agonist-1 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

A2A/A3 agonist-1 is a dual A2A/A3 adenosine receptor agonist. A2A/A3 agonist-1 has a Ki value of 2.9 nM and an EC50 of 0.51 nM for hA2AAR. A2A/A3 agonist-1 has a Ki of 0.8 nM and an EC50 < 0.10 nM for hA3AR. A2A/A3 agonist-1 possesses anti-inflammatory activity and can be used for the research of inflammatory diseases[1].

In Vitro

A2A/A3 agonist-1 (10-50 nM; 24 h) exhibits potent inhibitory effects on IL-12/IL-23p40 and IL-6 in LPS (HY-D1056)-stimulated bone marrow-derived dendritic cells (BMDCs)1.
A2A/A3 agonist-1 (1 μM; 0-60 min) shows favorable metabolic stability in human liver microsomes and plasma with no meaningful hERG inhibition1.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A2A/A3 agonist-1 Related Antibodies

ELISA Assay[1]

Cell Line: LPS treated BMDCs
Concentration: 10,50 nM
Incubation Time: 24h
Result: Inhibited the production of IL-12/IL-23p40 and IL-6.
Molecular Weight

404.49

Formula

C18H24N6O3S
SMILES

O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC(C#CCCCC)=N3)S[C@@H]1C(NCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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A2A/A3 agonist-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A2A/A3 agonist-1Adenosine ReceptorP1 receptorA3 adenosine receptor agonistAnti-inflammatoryreceptor dual agonistA2A adenosine receptor agonistBMDCsInhibitorinhibitorinhibit

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