A2A/A3 agonist-1
A2A/A3 agonist-1 is a dual A2A/A3 adenosine receptor agonist. A2A/A3 agonist-1 has a Ki value of 2.9 nM and an EC50 of 0.51 nM for hA2AAR. A2A/A3 agonist-1 has a Ki of 0.8 nM and an EC50 < 0.10 nM for hA3AR. A2A/A3 agonist-1 possesses anti-inflammatory activity and can be used for the research of inflammatory diseases.
For research use only. We do not sell to patients.
- Formula: C18H24N6O3S
- Molecular Weight:404.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Adenosine Receptor Isoforms
More
Biological Activity
A2A/A3 agonist-1 (10-50 nM; 24 h) exhibits potent inhibitory effects on IL-12/IL-23p40 and IL-6 in LPS (HY-D1056)-stimulated bone marrow-derived dendritic cells (BMDCs)1.
A2A/A3 agonist-1 (1 μM; 0-60 min) shows favorable metabolic stability in human liver microsomes and plasma with no meaningful hERG inhibition1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:LPS treated BMDCs
-
Concentration:10,50 nM
-
Incubation Time:24h
-
Result:Inhibited the production of IL-12/IL-23p40 and IL-6.
Chemical Information
-
Molecular Weight 404.49
-
Formula C18H24N6O3S
-
SMILES
O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC(C#CCCCC)=N3)S[C@@H]1C(NCC)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz