2. GPCR/G Protein
  3. Adenosine Receptor
  4. TC-G 1004

TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively.

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TC-G 1004 Chemical Structure

TC-G 1004 Chemical Structure

CAS No. : 1061747-72-5

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TC-G 1004 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively[1].

IC50 & Target

Ki: 0.44 nM (hA2A), 80 nM (hA1)[1].
In Vitro

TC-G 1004 (compound 16j) is a highly potent A2A antagonist at both the human and rat receptors with greater than 100× selectivity over hA1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TC-G 1004 Related Antibodies
In Vivo

TC-G 1004 (compound 16j, 3 mg/kg) displays good in vivo oral activity in rat models for Parkinson’s disease and were advanced to preclinical development[1].
TC-G 1004 (compound 16j) dose-dependently potentiates L-dopa induced rotations with an MED of 3 mg/kg when dosed orally[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

421.50

Formula

C22H27N7O2
CAS No.
SMILES

CC(NC1=NC(N2N=C(C)C=C2C)=NC(C3=NC(N4CCC(OC)CC4)=CC=C3)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TC-G 1004 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC-G 10041061747-72-5Adenosine ReceptorP1 receptorParkinson’sdiseaseInhibitorinhibitorinhibit

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TC-G 1004
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