1. GPCR/G Protein
  2. Adenosine Receptor
  3. TC-G 1004

TC-G 1004 

Cat. No.: HY-14365
Handling Instructions

TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively.

For research use only. We do not sell to patients.

TC-G 1004 Chemical Structure

TC-G 1004 Chemical Structure

CAS No. : 1061747-72-5

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Description

TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively[1].

IC50 & Target

Ki: 0.44 nM (hA2A), 80 nM (hA1)[1].

In Vitro

TC-G 1004 (compound 16j) is a highly potent A2A antagonist at both the human and rat receptors with greater than 100× selectivity over hA1[1].

In Vivo

TC-G 1004 (compound 16j, 3 mg/kg) displays good in vivo oral activity in rat models for Parkinson’s disease and were advanced to preclinical development[1].
TC-G 1004 (compound 16j) dose-dependently potentiates L-dopa induced rotations with an MED of 3 mg/kg when dosed orally[1].

Molecular Weight

421.50

Formula

C₂₂H₂₇N₇O₂

CAS No.

1061747-72-5

SMILES

CC(NC1=NC(N2N=C(C)C=C2C)=NC(C3=NC(N4CCC(OC)CC4)=CC=C3)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TC-G 1004Adenosine ReceptorP1 receptorParkinson’sdiseaseInhibitorinhibitorinhibit

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