Benzo[c][1,8]naphthyridin-6(5H)-one
Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM.
For research use only. We do not sell to patients.
- CAS No.: 53439-81-9
- Formula: C12H8N2O
- Molecular Weight:196.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![Benzo[c][1,8]naphthyridin-6(5H)-one Chemical Structure](https://file.medchemexpress.com/product_pic/hy-115862.gif "Click to View Benzo[c][1,8]naphthyridin-6(5H)-one Chemical Structure")
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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PARP-1 0.311 μM (IC50) |
Aurora A 5.5 μM (IC50) |
hA1AR 4.6 μM (Ki) |
hA2AAR 4.8 μM (Ki) |
Chemical Information
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CAS No. 53439-81-9
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Molecular Weight 196.20
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Formula C12H8N2O
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SMILES
O=C1NC2=NC=CC=C2C3=CC=CC=C13
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. van der Horst E, et al., Multi-objective evolutionary design of adenosine receptor ligands. J Chem Inf Model. 2012 Jul 23;52(7):1713-21. [Content Brief]
[2]. Ferraris D, et al., Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries. J Med Chem. 2003 Jul 3;46(14):3138-51. [Content Brief]
[3]. Karra S, et al., SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg Med Chem Lett. 2013 May 15;23(10):3081-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Benzo[c][1,8]naphthyridin-6(5H)-one Related Classifications
HY-115862 Related Classifications
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