Benzo[c][1,8]naphthyridin-6(5H)-one
Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM.
For research use only. We do not sell to patients.
- CAS No.: 53439-81-9
- Formula: C12H8N2O
- Molecular Weight:196.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![Benzo[c][1,8]naphthyridin-6(5H)-one Chemical Structure](https://file.medchemexpress.com/product_pic/hy-115862.gif "Click to View Benzo[c][1,8]naphthyridin-6(5H)-one Chemical Structure")
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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PARP-1 0.311 μM (IC50) |
Aurora A 5.5 μM (IC50) |
hA1AR 4.6 μM (Ki) |
hA2AAR 4.8 μM (Ki) |
Chemical Information
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CAS No. 53439-81-9
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Molecular Weight 196.20
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Formula C12H8N2O
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SMILES
O=C1NC2=NC=CC=C2C3=CC=CC=C13
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. van der Horst E, et al., Multi-objective evolutionary design of adenosine receptor ligands. J Chem Inf Model. 2012 Jul 23;52(7):1713-21. [Content Brief]
[2]. Ferraris D, et al., Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries. J Med Chem. 2003 Jul 3;46(14):3138-51. [Content Brief]
[3]. Karra S, et al., SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg Med Chem Lett. 2013 May 15;23(10):3081-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Benzo[c][1,8]naphthyridin-6(5H)-one Related Classifications
HY-115862 Related Classifications
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