53439-81-9
![Benzo[c][1,8]naphthyridin-6(5H)-one Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-115862.gif "Benzo[c][1,8]naphthyridin-6(5H)-one Chemical Structure")
53439-81-9
Chemical Structure
Benzo[c][1,8]naphthyridin-6(5H)-one
- CAS No.: 53439-81-9
- Formula:C12H8N2O
- Molecular Weight:196.20
IUPAC Name: benzo[c][1,8]naphthyridin-6(5H)-one
InChIKey: YLSBDRGLLZDAKB-UHFFFAOYSA-N
SMILES: O=C1NC2=NC=CC=C2C3=CC=CC=C13
Biological Activity: Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM[1][2][3].
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Benzo[c][1,8]naphthyridin-6(5H)-one | Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A1 and hA2A, with Ki of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC50 of 0.311 and 5.5 μM. | |||||||||||||||||||||
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References
- [1]. van der Horst E, et al., Multi-objective evolutionary design of adenosine receptor ligands. J Chem Inf Model. 2012 Jul 23;52(7):1713-21. [Content Brief]
- [2]. Ferraris D, et al., Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries. J Med Chem. 2003 Jul 3;46(14):3138-51. [Content Brief]
- [3]. Karra S, et al., SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg Med Chem Lett. 2013 May 15;23(10):3081-7. [Content Brief]
Keywords
