1. GPCR/G Protein
  2. Adenosine Receptor
  3. PSB-10 hydrochloride

PSB-10 hydrochloride 

Cat. No.: HY-103177
Handling Instructions

PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice.

For research use only. We do not sell to patients.

PSB-10 hydrochloride Chemical Structure

PSB-10 hydrochloride Chemical Structure

CAS No. : 591771-91-4

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Description

PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice[1][2].

IC50 & Target

Ki: 0.44 nM (hA3AR)[2]

In Vitro

PSB-10 hydrochloride exhibits a subnanomolar Ki value (Ki=0.43 nM versus [3H]NECA) for A3AR. In addition, R-8 is highly selective (>800-fold) versus the other AR subtypes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PSB-10 hydrochloride (50-100 mg/kg; i.p.) dose-dependently decreases hot-plate response latencies in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

435.14

Formula

C₁₆H₁₅Cl₄N₅O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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PSB-10 hydrochloride
Cat. No.:
HY-103177
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