591771-91-4
Chemical Structure
PSB-10 hydrochloride
- CAS No.: 591771-91-4
- Formula:C16H15Cl4N5O
- Molecular Weight:435.14
IUPAC Name: (R)-8-ethyl-4-methyl-2-(2,3,5-trichlorophenyl)-3,4,7,8-tetrahydro-5H-imidazo[2,1-i]purin-5-one hydrochloride
InChIKey: JUPMOTHIKGWECW-DDWIOCJRSA-N
SMILES: O=C1N(C)C2=C(N=C(C3=CC(Cl)=CC(Cl)=C3Cl)N2)C4=N[C@H](CC)CN14.[H]Cl
Biological Activity: PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice[1][2].
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PSB-10 hydrochloride | PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice. | |||||||||||||||||||||
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- [1]. Ozola V, et, al. 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors. Bioorg Med Chem. 2003 Feb 6;11(3):347-56. [Content Brief]
- [2]. Abo-Salem OM, et, al. Antinociceptive effects of novel A2B adenosine receptor antagonists. J Pharmacol Exp Ther. 2004 Jan;308(1):358-66. [Content Brief]
Keywords
