2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Adenosine Receptor Carbonic Anhydrase
  4. hA2A/hCA XII modulator 1

hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research.

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hA2A/hCA XII modulator 1

hA2A/hCA XII modulator 1 Chemical Structure

CAS No. : 2548963-55-7

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hA2A/hCA XII modulator 1 Related Antibodies

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CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

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Description

hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research[1].

IC50 & Target[1]

CA XII

 

CA Ⅱ

 

hA2AAR

6.4 nM (Ki)

hA1AR

4.819 μM (Ki)

hA3

>30 μM (Ki)

Masse moléculaire

501.52

Formule

C24H19N7O4S
CAS No.
SMILES

O=C(NC1=CC=C(C2=CN3C(C(N)=N2)=NN(C4=CC=CC=C4)C3=O)C=C1)C5=CC=C(S(=O)(N)=O)C=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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hA2A/hCA XII modulator 1 Related Classifications

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Keywords:

hA2A/hCA XII modulator 12548963-55-7Adenosine ReceptorCarbonic AnhydraseP1 receptorCarbonate dehydratasetriazolopirazinehA2Aadenosine receptorhA2A ARhA1 ARhA3 ARhCA XIIhCA IIhCA IXhCA IcancerInhibitorinhibitorinhibit

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