2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Adenosine Receptor Carbonic Anhydrase
  4. hA2A/hCA XII modulator 1

hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research.

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hA2A/hCA XII modulator 1 Chemical Structure

hA2A/hCA XII modulator 1 Chemical Structure

CAS No. : 2548963-55-7

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hA2A/hCA XII modulator 1 Related Antibodies

Top Publications Citing Use of Products

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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CA CA I CA Ⅱ CA Ⅸ CA XII

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Description

hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research[1].

IC50 & Target[1]

hA2AAR

6.4 nM (Ki)

hA1AR

4.819 μM (Ki)

hA3

>30 μM (Ki)

Molecular Weight

501.52

Formula

C24H19N7O4S
CAS No.
SMILES

O=C(NC1=CC=C(C2=CN3C(C(N)=N2)=NN(C4=CC=CC=C4)C3=O)C=C1)C5=CC=C(S(=O)(N)=O)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hA2A/hCA XII modulator 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hA2A/hCA XII modulator 12548963-55-7Adenosine ReceptorCarbonic AnhydraseP1 receptorCarbonate dehydratasetriazolopirazinehA2A,?adenosine receptorhA2A ARhA1 ARhA3 ARhCA XIIhCA IIhCA IXhCA I,?cancerInhibitorinhibitorinhibit

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