Search Result
Results for "
IgG4 κ monoclonal antibody
" in MedChemExpress (MCE) Product Catalog:
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P99971
-
|
|
ADC Antibody
Transmembrane Glycoprotein
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Cancer
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Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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-
-
- HY-P990070
-
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BION-1301
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TNF Receptor
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Zigakibart (BION-1301) is an IgG4-kappa, humanized monoclonal antibody against TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256). Zigakibart exhibits anti-inflammatory activity .
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-
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- HY-P9971
-
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SHR-1210; INCSHR1210
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PD-1/PD-L1
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Cancer
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Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1. Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC50 of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al .
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- HY-P99453
-
|
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ADC Antibody
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Cancer
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Azintuxizumab is an anti-SLAMF7 human IgG4κ monoclonal antibody. Azintuxizumab can be used in the synthesis of antibody-drug conjugate (ADC), Azintuxizumab vedotin .
|
-
-
- HY-P99299
-
|
HGS-ETR 2; ETR2-ST01
|
Apoptosis
|
Cancer
|
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Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research .
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- HY-P990091
-
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SAR 445088
|
Complement System
|
Inflammation/Immunology
|
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Riliprubart (SAR 445088) is an anti-C1s humanized IgG4 monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a. Riliprubart can be used to study complement-mediated diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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-
-
- HY-P99613
-
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MK-4280; Mavezelimab
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LAG-3
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Cancer
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Favezelimab (MK-4280) is a humanized monoclonal antibody targeting LAG-3. Favezelimab blocks the interaction between LAG-3 and its ligand, MHC class II molecules. Favezelimab is applicable to research on relapsed/refractory classical Hodgkin lymphoma, relapsed/refractory diffuse large B-cell lymphoma, and relapsed/refractory indolent B-cell lymphoma . For the isotype control of Favezelimab, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P991201
-
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Interleukin Related
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Inflammation/Immunology
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REGN-7257 is a humanized monoclonal antibody targeting IL2RG. REGN-7257 blocks the signal transduction induced by common gamma chain (γc) cytokines via the IL2RG chain of the γc cytokine receptor complex. REGN-7257 is applicable for research on immune-mediated diseases and T cell-mediated diseases . Its corresponding isotype control is Human IgG4 kappa, Isotype Control (HY-P99003).
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-
- HY-P990737
-
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LY-3041658
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CXCR
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Inflammation/Immunology
|
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Eltrekibart is an anti-CXCL human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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-
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- HY-P990773
-
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LY-3361237
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CD28
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Inflammation/Immunology
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Venanprubart is an anti-BTLA human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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-
- HY-P990726
-
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KPL-404
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TNF Receptor
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Inflammation/Immunology
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Abiprubart is an anti-CD40 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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-
-
- HY-P991301
-
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LAG-3
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Cancer
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IMP-761 is a human IgG4 monoclonal antibody (mAb) targeting CD223/LAG3. IMP-761 binds to D1 of human LAG32. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
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- HY-P991183
-
|
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CD28
CD38
CD3
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Cancer
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SAR442257 is a humanized IgG4-S228P, kappa monoclonal antibody targeting CD38 and CD28 on multiple myeloma cells and co-stimulates CD3 and CD28 on T cells .
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- HY-P990751
-
-
-
- HY-P991067
-
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KP-104
|
Complement System
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Inflammation/Immunology
|
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Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .
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- HY-P990750
-
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IBI-110
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LAG-3
|
Inflammation/Immunology
|
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Negalstobart is an anti-LAG3 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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-
- HY-P990691
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-
-
- HY-P991574
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REG-101
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ATGL
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Cardiovascular Disease
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MEDI-5884 is a humanized IgG4Pκ neutralizing monoclonal antibody targeting Endothelial lipase (EL). MEDI-5884 inhibits EL and increases quantity (particularly phosphatidylinositols and cholesteryl esters) and function of high-density lipoproteins (HDL). MEDI-5884 can be used for cardiovascular disease like coronary artery disease (CAD) research .
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- HY-P991070
-
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TNF Receptor
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Cancer
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ADG-106 is a fully human agonistic monoclonal IgG4 antibody against CD137 (4-1BB). ADG-106 has the mechanism to activate CD137 via strong FcγRIIB-mediated crosslinking while antagonizing CD137 ligands. The isotype control for ADG-106 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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- HY-P991166
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Mucin
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Others
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Ubletamig is an anti-MUC16 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
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-
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- HY-P991169
-
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Factor Xa
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Cardiovascular Disease
|
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Zemocimig is an anti-coagulation factor F9 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
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- HY-P990752
-
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REGN-5678
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CD28
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Inflammation/Immunology
|
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Nezastomig is an anti-FOLH1/CD28 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P990072
-
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LZM-009
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PD-1/PD-L1
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Cancer
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Lipustobart is an IgG4-kappa, anti-PDCD1 (programmed cell death 1, PD1, PD-1, CD279) humanized monoclonal antibody. Lipustobart shows immunostimulant and antineoplastic activity .
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- HY-P991721
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|
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PCSK9
|
Cardiovascular Disease
|
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Ticalicibart is a humanized IgG4κ monoclonal antibody inhibitor targeting PCSK9. Ticalicibart has anti-hyperlipidaemic activity. Ticalicibart can be used for cardiovascular disease like hypercholesterolaemia research .
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-
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- HY-P991393
-
|
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Transmembrane Glycoprotein
IFNAR
TNF Receptor
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Cancer
|
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ASP8374 is a human IgG4 monoclonal antibody (mAb) targeting TIGIT. ASP8374 increases IL-2 production in Jurkat cells and IFN-γ and TNF-α production in human PBMCs. ASP8374 can be used in advanced solid tumors research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
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- HY-P991708
-
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REGN-4336
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PSMA
CD3
|
Cancer
|
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Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. Olsutamig simultaneously binds to PSMA on the tumor cell surface and CD3E on the T cell surface, markedly activating T cells and thereby specifically killing prostate cancer cells .
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- HY-P991253
-
|
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IGF-1R
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Cancer
|
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BIIB022 is a human IgG4 monoclonal antibody (mAb) targeting IGF1R/CD221. BIIB022 blocks IGF-1 and IGF-2-induced phosphorylation of IGF-1R and downstream substrates. BIIB022 can be used in lung, pancreatic, and colon cancer research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
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- HY-P991117
-
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REGN-9933
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Factor Xa
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Cardiovascular Disease
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Amrecibart is an anti-coagulation factor 11 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
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- HY-P990702
-
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LVGN-3616
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PD-1/PD-L1
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Inflammation/Immunology
|
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Pradusinstobart is an anti-PDCD1 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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-
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- HY-P990761
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-
-
- HY-P991340
-
|
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PAI-1
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Cardiovascular Disease
|
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CT140 is a human IgG4 monoclonal antibody (mAb) targeting PAI-1. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).
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-
-
- HY-P990692
-
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JNJ-70218902; JNJ-902
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CD3
|
Inflammation/Immunology
|
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Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P991489
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Interleukin Related
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Inflammation/Immunology
|
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ENx-108A is a human IgG4 monoclonal antibody (mAb) targeting IL-11. BI-765423 can be used in fibrotic diseases research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
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- HY-P99668
-
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PD-1/PD-L1
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Cancer
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Iparomlimab is an anti-human PD-1/CD279/PDCD1 IgG4κ antibody. Iparomlimab also targets to human monoclonal PSB103 γ4-chain, disulfided with human monoclonal PSB103 κ-chain to form a dimer. Iparomlimab can be used for Oncology research .
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- HY-P991688
-
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Interleukin Related
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Inflammation/Immunology
|
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Gimvekibart is a humanized IgG4κ monoclonal antibody inhibitor targeting IL-4Ra/CD124. Gimvekibart can be used for inflammatory diseases like idiopathic pulmonary fibrosis (IPF) research .
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- HY-P991620
-
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Transmembrane Glycoprotein
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Cancer
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JS006 is a humanized IgG4κ monoclonal antibody inhibitor targeting TIGIT/CD155. JS006 can be used to study advanced and/or metastatic cancers with resistance to PD-1/PD-L1 inhibitor such as non-small cell lung cancer (NSCLC), advanced lymphoma and advanced/metastatic triple negative breast cancer (TNBC) .
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- HY-P991452
-
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Orexin Receptor (OX Receptor)
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Cancer
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Anti-CD200R1/OX2R Antibody (I-4P) is a human monoclonal antibody (mAb) targeting CD200R1/OX2R. Anti-CD200R1/OX2R Antibody (I-4P) can be used in solid tumors research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
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- HY-P990777
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-
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- HY-P992116
-
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TAM Receptor
|
Cancer
|
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Ladarutatug is a humanized monoclonal antibody targeting Tyrosine-protein kinase receptor UFO. The Ladarutatug antibody isotype is human IgG4κ; the recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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- HY-P992115
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Integrin
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Cancer
|
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Furtisetabart is a humanized monoclonal antibody targeting CD147 with anti-tumor activity. Furtisetabart is of the human IgG4κ antibody subtype, and the recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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- HY-P992125
-
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HFB-200603
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CD28
|
Cancer
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Radanstobart (HFB-200603) is a humanized monoclonal antibody targeting CD272 with antitumor activity. Radanstobart is of the human IgG4κ isotype, and the recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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- HY-P991963
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ERK
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Others
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Anti-Big-ET-1 Antibody is a humanized monoclonal antibody targeting Big-ET-1. Recommended Isotype Control: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P992231
-
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TAM Receptor
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Inflammation/Immunology
|
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Anti-GAS6 Antibody (KM5321) is a humanized anti-GAS6 monoclonal antibody. Its isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P992192
-
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GDNF Receptor
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Inflammation/Immunology
|
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Anti-Artemin Antibody is a monoclonal antibody that targets artemin. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-artemin antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P992194
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Transmembrane Glycoprotein
|
Inflammation/Immunology
|
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Anti-BCAM Antibody is a monoclonal antibody that targets BCAM. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-BCAM Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P992182
-
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Interleukin Related
IFNAR
CD28
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Inflammation/Immunology
|
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ANB032 is a human IgG4 kappa BTLA agonist monoclonal antibody. ANB032 inhibits activated T cell proliferation and reduces secretion of inflammatory cytokines. ANB032 can be used for the research of atopic dermatitis[1].
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- HY-P992295
-
|
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Transmembrane Glycoprotein
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Inflammation/Immunology
|
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Anti-Protein S Antibody is a monoclonal antibody targeting Protein S. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Protein S Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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-
- HY-P992346
-
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CD47
|
Cancer
|
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DS-1103a is a humanized IgG4 monoclonal antibody targeting SIRPa/CD172a. DS-1103a inhibits the interaction between SIRPα and CD47. DS-1103a enhances antibody-dependent cellular phagocytosis of cancer cells. DS-1103a can be used for the research of solid tumors. The recommended isotype control is: Human IgG4 (S228P) kappa, (HY-P99003) .
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- HY-P992198
-
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CCR
|
Inflammation/Immunology
|
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Anti-CCL28 Antibody is a monoclonal antibody targeting CCL28. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CCL28 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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-
- HY-P992235
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- HY-P992249
-
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Interleukin Related
|
Inflammation/Immunology
|
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Anti-IL-34 Antibody is a monoclonal antibody that targets IL-34. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-34 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P992302
-
|
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Transmembrane Glycoprotein
|
Inflammation/Immunology
|
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Anti-SEMA3A Antibody is a monoclonal antibody targeting SEMA3A. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-SEMA3A Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P992225
-
|
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TNF Receptor
|
Inflammation/Immunology
|
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Anti-DR3 Antibody is a monoclonal antibody that targets DR3. Anti-DR3 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-DR3 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P992224
-
|
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Wnt
|
Inflammation/Immunology
|
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Anti-DKK2 Antibody is a monoclonal antibody that targets DKK2. Anti-DKK2 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-DKK2 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P992219
-
|
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Claudin
|
Inflammation/Immunology
|
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Anti-Claudin 1 Antibody is a monoclonal antibody targeting CLDN1/CLD1/SEMP1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Claudin 1 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P992280
-
|
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Integrin
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Inflammation/Immunology
|
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Anti-NRP2 Antibody is a monoclonal antibody targeting NRP2/VEGF165R2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NRP2 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
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- HY-P992484
-
|
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Tau Protein
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Neurological Disease
|
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VY7523 is a monoclonal antibody and a selective inhibitor of pathological Tau. VY7523 reduces the propagation of pathogenic Tau in transgenic mouse models. VY7523 can be used in the research of Alzheimer's disease. The isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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- HY-P992156
-
|
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LAG-3
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Cancer
|
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Anti-Human/Mouse/Bovine LAG-3 Antibody (ADI-31853) is a monoclonal antibody that specifically binds to human, mouse and bovine LAG-3. Anti-Human/Mouse/Bovine LAG-3 Antibody (ADI-31853) can be used in the research of colon cancer, colorectal cancer and rectal cancer. The recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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- HY-P992335
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Interleukin Related
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Cancer
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COM503 is a high-affinity anti-IL18BP human monoclonal antibody with a Kd value of 0.291 pM. COM503 binds to IL18BP, blocks the IL18BP:IL18 interaction, displaces IL18 from preformed complexes, and enhances the activation and function of T cells and NK cells. COM503 induces anti-tumor effects by relieving the activity inhibition of endogenous IL18 in the tumor microenvironment. COM503 can be used for cancer research. The recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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- HY-P991957
-
|
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Prion Protein
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Neurological Disease
|
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PRN100 is a fully humanized monoclonal antibody against cellular prion protein (PrPᶜ), belonging to the IgG4κ isotype. By binding to and stabilizing cellular prion protein, PRN100 is designed to prevent cellular prion protein from being recruited and converted into pathogenic, self-propagating prion (PrPˢᶜ) aggregates. PRN100 can be used for the study of Creutzfeldt-Jakob disease.
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- HY-P992382
-
|
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Interleukin Related
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Neurological Disease
Inflammation/Immunology
|
|
IC 100 is a humanized IgG4κ monoclonal antibody targeting apoptosis-associated speck-like protein (ASC) with blood-brain barrier permeability. IC 100 specifically inhibits ASC after being endocytosed via its Fc segment, blocks ASC polymerization and inflammasome activation, suppresses IL-1β release, forms complexes with ASC and TRIM21, and evades TRIM21-mediated proteasomal degradation. IC 100 alleviates symptoms associated with autoimmune encephalomyelitis, reduces immune cell infiltration and microglial activation in the mouse EAE model. IC 100 is suitable for research on neuroinflammatory and inflammasome-related diseases such as multiple sclerosis. Isotype comparison: HY-P99003 .
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| Cat. No. |
Product Name |
Target |
Research Area |
Image |
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- HY-P99003
-
-
(5)
-
- HY-P99971
-
|
|
ADC Antibody
Transmembrane Glycoprotein
|
Cancer
|
|
Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen. Gemtuzumab affects cell necrosis by specifically targeting CD33 expressed on the surface of leukaemic cell blasts in acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P99176
-
ATG-031
4 Publications Verification
|
Inhibitory Antibodies
|
Cancer
|
|
ATG-031 is a humanized anti-CD24 monoclonal antibody with high affinity and specificity. ATG-031 interacts with Siglec-10 expressed by tumor-associated macrophages. ATG-031 effectively stimulates macrophage-mediated phagocytosis and induces cancer cell destruction by blocking the anti-phagocytic surface proteins. ATG-031 can be used in the study of haematological malignancies as well as solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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-
(5)
-
- HY-P990070
-
|
BION-1301
|
TNF Receptor
|
|
|
Zigakibart (BION-1301) is an IgG4-kappa, humanized monoclonal antibody against TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256). Zigakibart exhibits anti-inflammatory activity .
|
-
(5)
-
- HY-P9971
-
|
SHR-1210; INCSHR1210
|
PD-1/PD-L1
|
Cancer
|
|
Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1. Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC50 of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al .
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-
(5)
-
- HY-P99453
-
|
|
ADC Antibody
|
Cancer
|
|
Azintuxizumab is an anti-SLAMF7 human IgG4κ monoclonal antibody. Azintuxizumab can be used in the synthesis of antibody-drug conjugate (ADC), Azintuxizumab vedotin .
|
-
(5)
-
- HY-P99299
-
|
HGS-ETR 2; ETR2-ST01
|
Apoptosis
|
Cancer
|
|
Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research .
|
-
(5)
-
- HY-P990091
-
|
SAR 445088
|
Complement System
|
Inflammation/Immunology
|
|
Riliprubart (SAR 445088) is an anti-C1s humanized IgG4 monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a. Riliprubart can be used to study complement-mediated diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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(5)
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- HY-P99613
-
|
MK-4280; Mavezelimab
|
LAG-3
|
Cancer
|
Favezelimab (MK-4280) is a humanized monoclonal antibody targeting LAG-3. Favezelimab blocks the interaction between LAG-3 and its ligand, MHC class II molecules. Favezelimab is applicable to research on relapsed/refractory classical Hodgkin lymphoma, relapsed/refractory diffuse large B-cell lymphoma, and relapsed/refractory indolent B-cell lymphoma . For the isotype control of Favezelimab, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P991201
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
REGN-7257 is a humanized monoclonal antibody targeting IL2RG. REGN-7257 blocks the signal transduction induced by common gamma chain (γc) cytokines via the IL2RG chain of the γc cytokine receptor complex. REGN-7257 is applicable for research on immune-mediated diseases and T cell-mediated diseases . Its corresponding isotype control is Human IgG4 kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P990737
-
|
LY-3041658
|
CXCR
|
Inflammation/Immunology
|
|
Eltrekibart is an anti-CXCL human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P990773
-
|
LY-3361237
|
CD28
|
Inflammation/Immunology
|
|
Venanprubart is an anti-BTLA human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P990743
-
|
AB023; Xisomab 3G3; MAB 14E11
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
|
Gruticibart is an anti-F11 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P990726
-
|
KPL-404
|
TNF Receptor
|
Inflammation/Immunology
|
|
Abiprubart is an anti-CD40 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P991301
-
|
|
LAG-3
|
Cancer
|
|
IMP-761 is a human IgG4 monoclonal antibody (mAb) targeting CD223/LAG3. IMP-761 binds to D1 of human LAG32. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P991183
-
|
|
CD28
CD38
CD3
|
Cancer
|
|
SAR442257 is a humanized IgG4-S228P, kappa monoclonal antibody targeting CD38 and CD28 on multiple myeloma cells and co-stimulates CD3 and CD28 on T cells .
|
-
(5)
-
- HY-P990751
-
-
(5)
-
- HY-P990770
-
-
(5)
-
- HY-P991067
-
|
KP-104
|
Complement System
|
Inflammation/Immunology
|
|
Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .
|
-
(5)
-
- HY-P990750
-
|
IBI-110
|
LAG-3
|
Inflammation/Immunology
|
|
Negalstobart is an anti-LAG3 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P990691
-
-
(5)
-
- HY-P991574
-
|
REG-101
|
ATGL
|
Cardiovascular Disease
|
|
MEDI-5884 is a humanized IgG4Pκ neutralizing monoclonal antibody targeting Endothelial lipase (EL). MEDI-5884 inhibits EL and increases quantity (particularly phosphatidylinositols and cholesteryl esters) and function of high-density lipoproteins (HDL). MEDI-5884 can be used for cardiovascular disease like coronary artery disease (CAD) research .
|
-
(5)
-
- HY-P991070
-
|
|
TNF Receptor
|
Cancer
|
|
ADG-106 is a fully human agonistic monoclonal IgG4 antibody against CD137 (4-1BB). ADG-106 has the mechanism to activate CD137 via strong FcγRIIB-mediated crosslinking while antagonizing CD137 ligands. The isotype control for ADG-106 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P991166
-
|
|
Mucin
|
Others
|
|
Ubletamig is an anti-MUC16 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P991169
-
|
|
Factor Xa
|
Cardiovascular Disease
|
|
Zemocimig is an anti-coagulation factor F9 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P990752
-
|
REGN-5678
|
CD28
|
Inflammation/Immunology
|
|
Nezastomig is an anti-FOLH1/CD28 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P990072
-
|
LZM-009
|
PD-1/PD-L1
|
Cancer
|
|
Lipustobart is an IgG4-kappa, anti-PDCD1 (programmed cell death 1, PD1, PD-1, CD279) humanized monoclonal antibody. Lipustobart shows immunostimulant and antineoplastic activity .
|
-
(5)
-
- HY-P991721
-
|
|
PCSK9
|
Cardiovascular Disease
|
|
Ticalicibart is a humanized IgG4κ monoclonal antibody inhibitor targeting PCSK9. Ticalicibart has anti-hyperlipidaemic activity. Ticalicibart can be used for cardiovascular disease like hypercholesterolaemia research .
|
-
(5)
-
- HY-P991393
-
|
|
Transmembrane Glycoprotein
IFNAR
TNF Receptor
|
Cancer
|
|
ASP8374 is a human IgG4 monoclonal antibody (mAb) targeting TIGIT. ASP8374 increases IL-2 production in Jurkat cells and IFN-γ and TNF-α production in human PBMCs. ASP8374 can be used in advanced solid tumors research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P991708
-
|
REGN-4336
|
PSMA
CD3
|
Cancer
|
|
Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. Olsutamig simultaneously binds to PSMA on the tumor cell surface and CD3E on the T cell surface, markedly activating T cells and thereby specifically killing prostate cancer cells .
|
-
(5)
-
- HY-P991253
-
|
|
IGF-1R
|
Cancer
|
|
BIIB022 is a human IgG4 monoclonal antibody (mAb) targeting IGF1R/CD221. BIIB022 blocks IGF-1 and IGF-2-induced phosphorylation of IGF-1R and downstream substrates. BIIB022 can be used in lung, pancreatic, and colon cancer research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P991117
-
|
REGN-9933
|
Factor Xa
|
Cardiovascular Disease
|
|
Amrecibart is an anti-coagulation factor 11 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P990696
-
-
(5)
-
- HY-P990702
-
|
LVGN-3616
|
PD-1/PD-L1
|
Inflammation/Immunology
|
|
Pradusinstobart is an anti-PDCD1 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P990761
-
-
(5)
-
- HY-P991340
-
|
|
PAI-1
|
Cardiovascular Disease
|
|
CT140 is a human IgG4 monoclonal antibody (mAb) targeting PAI-1. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P990683
-
-
(5)
-
- HY-P990692
-
|
JNJ-70218902; JNJ-902
|
CD3
|
Inflammation/Immunology
|
|
Ciduvectamig is an anti-CD3E/TMEFF2 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P991489
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
ENx-108A is a human IgG4 monoclonal antibody (mAb) targeting IL-11. BI-765423 can be used in fibrotic diseases research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P99668
-
|
|
PD-1/PD-L1
|
Cancer
|
|
Iparomlimab is an anti-human PD-1/CD279/PDCD1 IgG4κ antibody. Iparomlimab also targets to human monoclonal PSB103 γ4-chain, disulfided with human monoclonal PSB103 κ-chain to form a dimer. Iparomlimab can be used for Oncology research .
|
-
(5)
-
- HY-P991688
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Gimvekibart is a humanized IgG4κ monoclonal antibody inhibitor targeting IL-4Ra/CD124. Gimvekibart can be used for inflammatory diseases like idiopathic pulmonary fibrosis (IPF) research .
|
-
(5)
-
- HY-P991620
-
|
|
Transmembrane Glycoprotein
|
Cancer
|
|
JS006 is a humanized IgG4κ monoclonal antibody inhibitor targeting TIGIT/CD155. JS006 can be used to study advanced and/or metastatic cancers with resistance to PD-1/PD-L1 inhibitor such as non-small cell lung cancer (NSCLC), advanced lymphoma and advanced/metastatic triple negative breast cancer (TNBC) .
|
-
(5)
-
- HY-P991452
-
|
|
Orexin Receptor (OX Receptor)
|
Cancer
|
|
Anti-CD200R1/OX2R Antibody (I-4P) is a human monoclonal antibody (mAb) targeting CD200R1/OX2R. Anti-CD200R1/OX2R Antibody (I-4P) can be used in solid tumors research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P990777
-
-
(5)
-
- HY-P992116
-
|
|
TAM Receptor
|
Cancer
|
|
Ladarutatug is a humanized monoclonal antibody targeting Tyrosine-protein kinase receptor UFO. The Ladarutatug antibody isotype is human IgG4κ; the recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P992115
-
|
|
Integrin
|
Cancer
|
|
Furtisetabart is a humanized monoclonal antibody targeting CD147 with anti-tumor activity. Furtisetabart is of the human IgG4κ antibody subtype, and the recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P992125
-
|
HFB-200603
|
CD28
|
Cancer
|
|
Radanstobart (HFB-200603) is a humanized monoclonal antibody targeting CD272 with antitumor activity. Radanstobart is of the human IgG4κ isotype, and the recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
|
-
(5)
-
- HY-P991963
-
|
|
ERK
|
Others
|
|
Anti-Big-ET-1 Antibody is a humanized monoclonal antibody targeting Big-ET-1. Recommended Isotype Control: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P992231
-
|
|
TAM Receptor
|
Inflammation/Immunology
|
|
Anti-GAS6 Antibody (KM5321) is a humanized anti-GAS6 monoclonal antibody. Its isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
-
- HY-P992192
-
|
|
GDNF Receptor
|
Inflammation/Immunology
|
|
Anti-Artemin Antibody is a monoclonal antibody that targets artemin. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-artemin antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
- HY-P992194
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-BCAM Antibody is a monoclonal antibody that targets BCAM. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-BCAM Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
- HY-P992182
-
|
|
Interleukin Related
IFNAR
CD28
|
Inflammation/Immunology
|
|
ANB032 is a human IgG4 kappa BTLA agonist monoclonal antibody. ANB032 inhibits activated T cell proliferation and reduces secretion of inflammatory cytokines. ANB032 can be used for the research of atopic dermatitis[1].
|
-
(5)
- HY-P992295
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-Protein S Antibody is a monoclonal antibody targeting Protein S. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Protein S Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
- HY-P992346
-
|
|
CD47
|
Cancer
|
|
DS-1103a is a humanized IgG4 monoclonal antibody targeting SIRPa/CD172a. DS-1103a inhibits the interaction between SIRPα and CD47. DS-1103a enhances antibody-dependent cellular phagocytosis of cancer cells. DS-1103a can be used for the research of solid tumors. The recommended isotype control is: Human IgG4 (S228P) kappa, (HY-P99003) .
|
-
(5)
- HY-P992198
-
|
|
CCR
|
Inflammation/Immunology
|
|
Anti-CCL28 Antibody is a monoclonal antibody targeting CCL28. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CCL28 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
- HY-P992235
-
-
(5)
- HY-P992249
-
|
|
Interleukin Related
|
Inflammation/Immunology
|
|
Anti-IL-34 Antibody is a monoclonal antibody that targets IL-34. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-34 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
- HY-P992302
-
|
|
Transmembrane Glycoprotein
|
Inflammation/Immunology
|
|
Anti-SEMA3A Antibody is a monoclonal antibody targeting SEMA3A. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-SEMA3A Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
- HY-P992225
-
|
|
TNF Receptor
|
Inflammation/Immunology
|
|
Anti-DR3 Antibody is a monoclonal antibody that targets DR3. Anti-DR3 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-DR3 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
- HY-P992224
-
|
|
Wnt
|
Inflammation/Immunology
|
|
Anti-DKK2 Antibody is a monoclonal antibody that targets DKK2. Anti-DKK2 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-DKK2 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
- HY-P992219
-
|
|
Claudin
|
Inflammation/Immunology
|
|
Anti-Claudin 1 Antibody is a monoclonal antibody targeting CLDN1/CLD1/SEMP1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Claudin 1 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
- HY-P992280
-
|
|
Integrin
|
Inflammation/Immunology
|
|
Anti-NRP2 Antibody is a monoclonal antibody targeting NRP2/VEGF165R2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NRP2 Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
|
-
(5)
- HY-P992484
-
|
|
Tau Protein
|
Neurological Disease
|
|
VY7523 is a monoclonal antibody and a selective inhibitor of pathological Tau. VY7523 reduces the propagation of pathogenic Tau in transgenic mouse models. VY7523 can be used in the research of Alzheimer's disease. The isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
|
-
(5)
- HY-P992156
-
|
|
LAG-3
|
Cancer
|
|
Anti-Human/Mouse/Bovine LAG-3 Antibody (ADI-31853) is a monoclonal antibody that specifically binds to human, mouse and bovine LAG-3. Anti-Human/Mouse/Bovine LAG-3 Antibody (ADI-31853) can be used in the research of colon cancer, colorectal cancer and rectal cancer. The recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
|
-
(5)
- HY-P992335
-
|
|
Interleukin Related
|
Cancer
|
|
COM503 is a high-affinity anti-IL18BP human monoclonal antibody with a Kd value of 0.291 pM. COM503 binds to IL18BP, blocks the IL18BP:IL18 interaction, displaces IL18 from preformed complexes, and enhances the activation and function of T cells and NK cells. COM503 induces anti-tumor effects by relieving the activity inhibition of endogenous IL18 in the tumor microenvironment. COM503 can be used for cancer research. The recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
|
-
(5)
- HY-P991957
-
|
|
Prion Protein
|
Neurological Disease
|
|
PRN100 is a fully humanized monoclonal antibody against cellular prion protein (PrPᶜ), belonging to the IgG4κ isotype. By binding to and stabilizing cellular prion protein, PRN100 is designed to prevent cellular prion protein from being recruited and converted into pathogenic, self-propagating prion (PrPˢᶜ) aggregates. PRN100 can be used for the study of Creutzfeldt-Jakob disease.
|
-
(5)
- HY-P992382
-
|
|
Interleukin Related
|
Neurological Disease
Inflammation/Immunology
|
|
IC 100 is a humanized IgG4κ monoclonal antibody targeting apoptosis-associated speck-like protein (ASC) with blood-brain barrier permeability. IC 100 specifically inhibits ASC after being endocytosed via its Fc segment, blocks ASC polymerization and inflammasome activation, suppresses IL-1β release, forms complexes with ASC and TRIM21, and evades TRIM21-mediated proteasomal degradation. IC 100 alleviates symptoms associated with autoimmune encephalomyelitis, reduces immune cell infiltration and microglial activation in the mouse EAE model. IC 100 is suitable for research on neuroinflammatory and inflammasome-related diseases such as multiple sclerosis. Isotype comparison: HY-P99003 .
|
-
(5)
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