Olsutamig
Based on 1 Customer Validation
Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. Olsutamig simultaneously binds to PSMA on the tumor cell surface and CD3E on the T cell surface, markedly activating T cells and thereby specifically killing prostate cancer cells.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.00%
- CAS 番号: 3034664-43-9
- 分子量:145.563 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
immunoglobulin (H-gamma4_L-kappa)_( Hgamma4_L-kappa)
Human
FOLH1/PSMA & CD3E
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG4-kappa
ELISA, FACS, Functional assay
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Immobilized PSMA Protein, Human (HEK293, HY-P70548A) can bind Olsutamig, The ED50 for this effect is 1.478 ng/mL. -
Immobilized CD3D-CD3E Heterodimer Protein, Human (HEK293, HY-P700677) can bind Olsutamig. The ED50 for this effect is 938.3 ng/mL.
化学情報
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CAS 番号 3034664-43-9
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性状 Liquid
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分子量 145.563 kDa
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Color Colorless to light yellow
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SMILES
N/A
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別名
REGN-4336
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)