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Riliprubart

(Synonyms: SAR 445088)
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Riliprubart (SAR 445088) is a selective anti-C1s humanized IgG4 monoclonal antibody with mutations that enhance its binding to the neonatal Fc receptor. Riliprubart blocks activation of the classical complement pathway, prevents the formation of the C3 convertase C4b2a, and inhibits complement-mediated hemolytic activity. Riliprubart can be used in research related to classical complement-mediated diseases, cold agglutinin disease, and chronic inflammatory demyelinating polyneuropathy. For the isotype control of Riliprubart, refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

For research use only. We do not sell to patients.

  • Purity: 99.90%
  • CAS No.: 2756228-76-7
  • Molecular Weight:145.52 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Riliprubart
  • Experimental Validation Results for Riliprubart
  • Experimental Validation Results for Riliprubart
  • Riliprubart Chemical Structure
  • Experimental Validation Results for Riliprubart
  • Experimental Validation Results for Riliprubart
  • Experimental Validation Results for Riliprubart
  • Riliprubart Chemical Structure
    Riliprubart Chemical Structure
CAS No.: 2756228-76-7
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized C1s/Complement component C1s Protein, Human (HEK293, His, HY-P700696) can bind Riliprubart. The EC50 for this effect is 3.783 ng/mL.

  • 1/16

    Flow Cytometry analysis of A549 cells labelling C1s (red) with Riliprubart (anti-C1s) (HY-P990091). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.

  • Riliprubart Chemical Structure
    1/16
  • Riliprubart
  • Immobilized C1s/Complement component C1s Protein, Human (HEK293, His, HY-P700696) can bind Riliprubart. The EC50 for this effect is 3.783 ng/mL.
  • Flow Cytometry analysis of A549 cells labelling C1s (red) with Riliprubart (anti-C1s) (HY-P990091). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.