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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
Neurokinin P
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "Neurokinin P" in MCE Product Catalog:
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33
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3
3 Cited Publications
Cat. No.: HY-W013375
CAS No.: 76721-89-6
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Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases .
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1 Cited Publications
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L-733060 hydrochloride is a selective neurokinin-1 (NK-1) receptor antagonist. L-733060 hydrochloride mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 hydrochloride blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 hydrochloride reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 hydrochloride hydrochloride inhibits neurogenic plasma extravasation at a dose that does not cause adverse cardiovascular effects in rodents, and also acts as an anti-tumor agent. L-733060 hydrochloride can be used for the study of chronic orofacial pain .
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1 Cited Publications
Cat. No.: HY-P1722
CAS No.: 129176-97-2
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Cat. No.: HY-W011978
CAS No.: 1218-34-4
Cat. No.: HY-P0242
CAS No.: 86933-75-7
Cat. No.: HY-P0242A
CAS No.: 101536-55-4
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Cardiovascular Disease Inflammation/Immunology Endocrinology
Cat. No.: HY-108483
CAS No.: 135911-02-3
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RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a Ki value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation .
Cat. No.: HY-P2546
CAS No.: 87468-58-4
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Cat. No.: HY-108482
CAS No.: 132746-60-2
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Cardiovascular Disease Neurological Disease Inflammation/Immunology
CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation .
Synonyms: GW679769B
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Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active neurokinin 1 (NK1) receptor antagonist. Casopitant mesylate is a second in the class of antiemetics that acts to antagonise the emetogenic effect of Substance P (HY-P0201). Casopitant mesylate is also a substrate and a weak-to-moderate inhibitor of CYP3A4. Casopitant mesylate can be used for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV) .
Cat. No.: HY-P0201AF
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Cat. No.: HY-P3801
CAS No.: 77128-69-9
Synonyms: DiMe-C7
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NK1 receptor antagonist 2 is a neurokinin 1 (NK1) receptor antagonist. NK1 receptor antagonist 2 is applicable to research related to tinnitus and hearing loss .
Cat. No.: HY-P3850
CAS No.: 109212-72-8
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Cat. No.: HY-P11312
CAS No.: 2770688-17-8
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Cat. No.: HY-P3852
CAS No.: 153607-26-2
Synonyms: SPR393-407
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Cat. No.: HY-P1738
CAS No.: 77128-75-7
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Cat. No.: HY-19665
CAS No.: 170566-84-4
Synonyms: LY303870
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Lanepitant (LY303870) is a selective neurokinin-1 (NK-1) receptor antagonist. Lanepitant blocks neurogenic inflammation and pain transmission by preventing the binding of substance P to NK-1 receptors on both neuronal and non-neuronal tissues. Lanepitant can be used to study osteoarthritis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
