1. GPCR/G Protein Neuronal Signaling
  2. Neurokinin Receptor
  3. [Sar9] Substance P

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Sar9] Substance P Chemical Structure

[Sar9] Substance P Chemical Structure

CAS No. : 77128-75-7

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1 mg USD 60 In-stock
5 mg USD 190 In-stock
10 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist[1].

IC50 & Target

Neurokinin (NK)-1 receptor[1]

Molecular Weight

1361.66

Formula

C64H100N18O13S

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-{SAR}-Leu-Met-NH2

Sequence Shortening

RPKPQQFF-{SAR}-LM-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (36.72 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7344 mL 3.6720 mL 7.3440 mL
5 mM 0.1469 mL 0.7344 mL 1.4688 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7344 mL 3.6720 mL 7.3440 mL 18.3599 mL
5 mM 0.1469 mL 0.7344 mL 1.4688 mL 3.6720 mL
10 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8360 mL
15 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2240 mL
20 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
25 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
30 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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[Sar9] Substance P Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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[Sar9] Substance P
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